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Literature summary for 3.6.5.2 extracted from

  • Fueller, F.; Schmidt, G.
    The polybasic region of Rho GTPases defines the cleavage by Yersinia enterocolitica outer protein T (YopT) (2008), Protein Sci., 17, 1456-1462.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.6.5.2

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
Yersinia outer protein T Yersinia outer protein T is a cysteine protease that cleaves Rho protein directly upstream of the post-translationally modified cysteine, thereby releasing the GTPase from the membrane leading to inactivation, farnesylated RhoA is a preferred substrate of Yersinia outer protein T compared with the geranylgeranylated GTPase, geranylgeranylated RhoA, however, is the preferred substrate for Yersinia outer protein T-catalyzed cleavage with a 3fold faster turnover rate over Rac and Cdc42 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
 Homo sapiens 16020
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
additional information small GTPases are modified by isoprenylation of the cysteine of the CAAX box, cleavage of the AAX tripeptide, and methylation of the cysteine, isoprenylation and the endoproteolytic cleavage of the tripeptide of Rho GTPases are essential for YopT-induced cleavage, whereas carboxyl methylation is not required Homo sapiens

Purification (Commentary)

Purification (Comment) Organism
-
 Homo sapiens

Synonyms

Synonyms Comment Organism
Cdc42
-
 Homo sapiens
Rac
-
 Homo sapiens
RhoA
-
 Homo sapiens