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Literature summary for 3.6.5.2 extracted from

  • Williams, D.A.; Zheng, Y.; Cancelas, J.A.
    Rho GTPases and regulation of hematopoietic stem cell localization (2008), Methods Enzymol., 439, 365-393.
    View publication on PubMed
Search for more literature for 3.6.5.2

Activating Compound

Activating Compound Comment Organism Structure
additional information growth factor receptor-induced activation of Cdc42 activates Rac, which in turn stimulates Rho activity Mus musculus
additional information Rac is activated via stimulation of the G-protein-coupled seven-span transmembrane receptor CXCR4 by stromal derived factor-1, by adhesion via beta1 integrins, and via stimulation of c-kit by the stem cell factor Mus musculus

Protein Variants

Protein Variants Comment Organism
D57N the dominant negative Rac GTPase mutation does not only inhibit Rac1, Rac2, and Rac3 activities, but may also inhibit Cdc42 Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
additional information RhoE downregulates the activity of RhoA by activating p190RhoGAP Mus musculus
NSC23766 a small molecule antagonist of Rac activation Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
chronic myeloid leukemia cell isoform Rac3 Mus musculus
-
hematopoietic stem cell
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
GTP + H2O
-
 Mus musculus GDP + phosphate
-
 ?

Synonyms

Synonyms Comment Organism
Cdc42
-
 Mus musculus
Rac1 isoform Mus musculus
Rac2 isoform Mus musculus
Rac3 isoform Mus musculus
Rac4 isoform Mus musculus
RhoA
-
 Mus musculus