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Literature summary for 3.6.5.2 extracted from

  • Carmona, G.; Goettig, S.; Orlandi, A.; Scheele, J.; Baeuerle, T.; Jugold, M.; Kiessling, F.; Henschler, R.; Zeiher, A.M.; Dimmeler, S.; Chavakis, E.
    Role of the small GTPase Rap1 for integrin activity regulation in endothelial cells and angiogenesis (2009), Blood, 113, 488-497.
    View publication on PubMed
Search for more literature for 3.6.5.2

Activating Compound

Activating Compound Comment Organism Structure
guanine nucleotide exchange factor Epac specifically increases Rap1 activity Mus musculus
guanine nucleotide exchange factor Epac specifically increases Rap1 activity Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
Rap1GAP1 a GTPase-activating protein that inhibits Rap1 activity Homo sapiens
Rap1GAP1 a GTPase-activating protein that inhibits Rap1 activity Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
 Homo sapiens 16020
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus Rap1 plays a critical role in the regulation of beta1-integrin affinity, adhesion, and migration in endothelial cells and in postnatal neovascularization ?
-
 ?
additional information Homo sapiens Rap1 plays a critical role in the regulation of beta1-integrin affinity, adhesion, and migration in endothelial cells and in postnatal neovascularization ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
endothelial cell
-
 Mus musculus
-
HUVEC cell
-
 Homo sapiens
-
umbilical vein endothelial cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
GTP + H2O
-
 Mus musculus GDP + phosphate
-
 ?
GTP + H2O
-
 Homo sapiens GDP + phosphate
-
 ?
additional information Rap1 plays a critical role in the regulation of beta1-integrin affinity, adhesion, and migration in endothelial cells and in postnatal neovascularization Mus musculus ?
-
 ?
additional information Rap1 plays a critical role in the regulation of beta1-integrin affinity, adhesion, and migration in endothelial cells and in postnatal neovascularization Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
Rap1
-
 Mus musculus
Rap1
-
 Homo sapiens
Ras-associated protein 1
-
 Mus musculus
Ras-associated protein 1
-
 Homo sapiens