Any feedback?
Literature summary for 3.6.5.2 extracted from
- Simulation of crosstalk between small GTPase RhoA and EGFR-ERK signaling pathway via MEKK1 (2009), Bioinformatics, 25, 358-364.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| farnesylthiosalicylic acid | markedly enhances RhoA level and activity | Homo sapiens |  |
| additional information | Ras inhibition and downregulation is expected to enhance RhoA activity | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| HEK-293 cell | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| GTP + H2O | - |
Homo sapiens | GDP + phosphate | - |
? | |
| MEK kinase 1 + H2O | RhoA binds and activates MEK kinase 1 | Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| RhoA | - |
Homo sapiens |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
