Activating Compound | Comment | Organism | Structure |
---|---|---|---|
UNC-73 | Trio-like guanine nucleotide exchange factor encoded by unc-73, acts as an activator of RHO-1 in the migration process, the UNC-73 GEF2 domain may have the exchange activity on RHO-1 in vivo | Caenorhabditis elegans |
Cloned (Comment) | Organism |
---|---|
T19N and G14V mutant rho-1 cDNA | Caenorhabditis elegans |
Protein Variants | Comment | Organism |
---|---|---|
G14V | constitutively active or gain of function | Caenorhabditis elegans |
additional information | eliminating or reducing rho-1 gene function by using a dominant-negative transgene or dsRNA interference results in a severe defect in migration of hypodermal P cells to a ventral position | Caenorhabditis elegans |
T19N | dominant negative mutation, phenotype | Caenorhabditis elegans |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
N-(2-chlorobenzyl)-N-[[(4-methylphenyl)sulfonyl]carbamoyl]-L-alanine | Rho toxin from Clostridium botulinum, ADP-ribosylates and specifically inactivates rho-1 | Caenorhabditis elegans |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
GTP + H2O | Caenorhabditis elegans | RHO-1 plays a role in hypodermal P cell migration to a ventral position during larval development | GDP + phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Caenorhabditis elegans | - |
wild-type strain N2 Bristol | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
GTP + H2O | - |
Caenorhabditis elegans | GDP + phosphate | - |
? | |
GTP + H2O | RHO-1 plays a role in hypodermal P cell migration to a ventral position during larval development | Caenorhabditis elegans | GDP + phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
RHO-1 | RhoA GTPase homologue | Caenorhabditis elegans |