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Literature summary for 3.6.5.2 extracted from
- Structural determinants required for the interaction between Rho GTPase and the GTPase-activating domain p190 (1997), J. Biol. Chem., 272, 32830-32835.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| GTPase activating protein GAP | p190, binding to and activation of RhoA and cdc42 | Homo sapiens |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expression in Escherichia coli | Homo sapiens |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| chimeras between RhoA/Cdc42 | residues 85-122 contain specific binding determinants for guanosine nucleotide activating protein, p190 | Homo sapiens |
| D90A | RhoA, significant decrease in p190-mediated stimulation of GTPase activity | Homo sapiens |
| S88D | Cdc42, enhancement of GTP-hydrolysis | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| GTP + H2O | Homo sapiens | - |
GDP + phosphate | - |
ir |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| GTP + H2O | - |
Homo sapiens | GDP + phosphate | - |
ir | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Cdc42 | Rho subfamily | Homo sapiens |
| RhoA | Rho subfamily | Homo sapiens |
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