Literature summary for 3.6.4.B1 extracted from

Dunn, S.; Morrison, E.E.; Liverpool, T.B.; Molina-Paris, C.; Cross, R.A.; Alonso, M.C.; Peckham, M.
Differential trafficking of Kif5c on tyrosinated and detyrosinated microtubules in live cells (2008), J. Cell Sci., 121, 1085-1095.

Search for more literature for 3.6.4.B1

Cloned(Commentary)

Cloned (Comment)	Organism
expression as fusion with green fluorescent protein in COS-7 cell	Rattus norvegicus

Protein Variants

Protein Variants	Comment	Organism
T93N	rigor-mutant, binds to microtubules but fails to move along them	Rattus norvegicus

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
microtubule	localization to a subset of microtubules in live cells. Puncta move at speeds of up to 1micrometer per s and exchange into cortically labelled clusters at microtubule ends. Movement is dependent on the presence of a functional motor domain	Rattus norvegicus	5874	-

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
additional information	Rattus norvegicus	kinesin-1 preferentially binds to and trafficks on detyrosinated microtubules in vivo, providing a potential bias for the spatial targeting of kinesin-1 based cargo transport	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	isoform KIF5C	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	kinesin-1 preferentially binds to and trafficks on detyrosinated microtubules in vivo, providing a potential bias for the spatial targeting of kinesin-1 based cargo transport	Rattus norvegicus	?	-	?

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Release 2023.1 (January 2023)