Literature summary for 3.6.4.B1 extracted from

Christodoulou, A.; Lederer, C.W.; Surrey, T.; Vernos, I.; Santama, N.
Motor protein KIFC5A interacts with Nubp1 and Nubp2, and is implicated in the regulation of centrosome duplication (2006), J. Cell Sci., 119, 2035-2047.

Search for more literature for 3.6.4.B1

Cloned(Commentary)

Cloned (Comment)	Organism
expression in mouse cell	Mus musculus

Protein Variants

Protein Variants	Comment	Organism
additional information	overexpression of KIFC5A in mouse cells causes the formation of aberrant, non-separated microtubule asters and mitotic arrest in a prometaphase-like state. KIFC5A knockdown partly rescues the phenotype caused by inhibition of plus-end directed motor Eg5 by monastrol on the mitotic spindle. Silencing also results in centrosome amplification detectable throughout the cell cycle. KIFC5A interacts with nucleotide-binding proteins 1 and 2. Knockdown of nucleotide-binding protein 1 or double knockdown of nucleotide-binding proteins 1 and 2 both phenocopy the KIFC5A silencing effect	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	isoform KIFC5A	-

Subunits

Subunits	Comment	Organism
More	KIFC5A interacts with nucleotide-binding proteins 1 and 2. Knockdown of nucleotide-binding protein 1 or double knockdown of nucleotide-binding proteins 1 and 2 both phenocopy the KIFC5A silencing effect	Mus musculus

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Release 2023.1 (January 2023)