Protein Variants | Comment | Organism |
---|---|---|
D662N | Walker-motif mutant: mutant shows a lower level of targeting to EGFP-Pex26p as compared to wild-type | Homo sapiens |
D803N | Walker-motif mutant: mutant is transported to peroxisomes by EGFP-Pex26p to the same level as wild-type | Homo sapiens |
D940N | Walker-motif mutant: mutant shows a normal or slightly increased level of targeting to EGFP-Pex26p as compared to wild-type | Homo sapiens |
K476E | Walker-motif mutant: mutant shows a lower level of targeting to EGFP-Pex26p as compared to wild-type | Homo sapiens |
K605E | Walker-motif mutant: mutant are significantly reduced in translocation to EGFP-Pex26p as compared to wild-type | Homo sapiens |
K750E | Walker-motif mutant: mutant shows a lower level of targeting to EGFP-Pex26p as compared to wild-type | Homo sapiens |
K887E | Walker-motif mutant: mutant are significantly reduced in translocation to EGFP-Pex26p as compared to wild-type | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
peroxisome | Pex1p is targeted to peroxisomes in a manner dependent on ATP hydrolysis. Transport of Pex1p and Pex6p is temperature-dependent | Homo sapiens | 5777 | - |
peroxisome | Pex6p targeting to peroxisomes requires ATP but not its hydrolysis. Transport of Pex1p and Pex6p is temperature-dependent | Homo sapiens | 5777 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | in vitro binding assays with GST-fused Pex26p show that Pex1p and Pex6p bind to Pex26p in a manner dependent on ATP binding but not ATP hydrolysis | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + H2O | - |
Homo sapiens | ADP + phosphate | - |
? | |
additional information | in vitro binding assays with GST-fused Pex26p show that Pex1p and Pex6p bind to Pex26p in a manner dependent on ATP binding but not ATP hydrolysis | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Pex1p | - |
Homo sapiens |
Pex6p | - |
Homo sapiens |