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Literature summary for 3.6.4.13 extracted from

  • Seo, M.; Seo, K.; Hwang, W.; Koo, H.J.; Hahm, J.H.; Yang, J.S.; Han, S.K.; Hwang, D.; Kim, S.; Jang, S.K.; Lee, Y.; Nam, H.G.; Lee, S.J.
    RNA helicase HEL-1 promotes longevity by specifically activating DAF-16/FOXO transcription factor signaling in Caenorhabditis elegans (2015), Proc. Natl. Acad. Sci. USA, 112, E4246-E4255.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.6.4.13

Cloned(Commentary)

Cloned (Comment) Organism
gene hel-1 Caenorhabditis elegans

Protein Variants

Protein Variants Comment Organism
additional information knockdown of hel-1 specifically decreases daf-2(-)-mediated longevity in an RNAi-hypersensitive rrf-3(pk1426) mutant background. hel-1 RNAi has a robust and specific effect on the longevity of daf-2 mutants. Resistance to heat stress is not affected by hel-1 mutations or RNAi, effects of hel-1 RNAi and hel-1 mutations on resistance to pathogenic bacteria (Pseudomonas aeruginosa, PA14) and oxidative stress are variable Caenorhabditis elegans

Organism

Organism UniProt Comment Textmining
Caenorhabditis elegans Q18212 gene hel-1
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Source Tissue

Source Tissue Comment Organism Textmining
intestine
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 Caenorhabditis elegans
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additional information hel-1 tissue expression patterns, overview Caenorhabditis elegans
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neuron
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 Caenorhabditis elegans
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Synonyms

Synonyms Comment Organism
DEAD-box RNA helicase
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 Caenorhabditis elegans
HEL-1
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 Caenorhabditis elegans
helicase 1
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 Caenorhabditis elegans
RNA helicase HEL-1
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 Caenorhabditis elegans

General Information

General Information Comment Organism
evolution RNA helicases are a large family of enzymes including evolutionarily conserved Hel-1 Caenorhabditis elegans
malfunction knockdown of several RNA helicases influences lifespan through the insulin/insulin-like growth factor 1 signaling pathway. Up-regulation of a large subset of genes in daf-2 mutants is affected by mutation hel-1 Caenorhabditis elegans
physiological function RNA helicases regulate the biogenesis and homeostasis of RNA, functional significance of RNA helicases in aging, a large fraction of RNA helicases regulate the lifespan of Caenorhabditis elegans. Enzyme Hel-1 promotes longevity by specifically activating the DAF-16/forkhead box O (FOXO) transcription factor signaling pathway. HEL-1 is required for the longevity conferred by reduced insulin/insulin-like growth factor 1 signaling and is sufficient for extending lifespan. The expression of HEL-1 in the intestine and neurons contributes to longevity. HEL-1 enhances the induction of a large fraction of DAF-16 target genes Caenorhabditis elegans