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Literature summary for 3.6.4.10 extracted from

  • Xu, M.; Marsh, H.; Sevier, C.
    A conserved cysteine within the ATPase domain of the endoplasmic reticulum chaperone BiP is necessary for a complete complement of BiP activities (2016), J. Mol. Biol., 428, 4168-4184 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.6.4.10

Protein Variants

Protein Variants Comment Organism
C63A the ATPase activity displayed by the unmodified ATPase domain Kar2 is fully maintained when Cys63 is replaced with Ala Saccharomyces cerevisiae
C63E the mutant shows limited ATPase activity Saccharomyces cerevisiae
C63F the mutation leads to loss of ATPase activity. The mutation supports an enhanced viability during oxidative stress associated with the oxidized ATPase domain Kar2 Saccharomyces cerevisiae
C63H the mutation supports an enhanced viability during oxidative stress associated with the oxidized ATPase domain Kar2 Saccharomyces cerevisiae
C63N the mutant shows limited ATPase activity Saccharomyces cerevisiae
C63P the mutation supports an enhanced viability during oxidative stress associated with the oxidized ATPase domain Kar2 Saccharomyces cerevisiae
C63V the ATPase activity displayed by the unmodified ATPase domain Kar2 is fully maintained when Cys63 is replaced with Val Saccharomyces cerevisiae
C63W the mutation leads to loss of ATPase activity. The mutation leads to loss of ATPase activity. The mutation supports an enhanced viability during oxidative stress associated with the oxidized ATPase domain Kar2 Saccharomyces cerevisiae
C63Y the mutation leads to loss of ATPase activity. The mutation supports an enhanced viability during oxidative stress associated with the oxidized ATPase domain Kar2 Saccharomyces cerevisiae

Localization

Localization Comment Organism GeneOntology No. Textmining
endoplasmic reticulum
-
 Saccharomyces cerevisiae 5783
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + H2O Saccharomyces cerevisiae
-
 ADP + phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O
-
 Saccharomyces cerevisiae ADP + phosphate
-
 ?

Subunits

Subunits Comment Organism
? x * 75000, SDS-PAGE Saccharomyces cerevisiae

Synonyms

Synonyms Comment Organism
ATP-dependent foldase
-
 Saccharomyces cerevisiae
BiP
-
 Saccharomyces cerevisiae
endoplasmic reticulum chaperone
-
 Saccharomyces cerevisiae
Kar2 ATPase domain of BiP Saccharomyces cerevisiae