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Literature summary for 3.6.4.10 extracted from

  • Pearl, L.
    Review The HSP90 molecular chaperone - an enigmatic ATPase (2016), Biopolymers, 105, 594-607 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.6.4.10

Activating Compound

Activating Compound Comment Organism Structure
Aha1 potent activator of the ATPase subunit of the enzyme Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
ATI3387 competitive inhibitor Homo sapiens
geldanamycin
-
 Homo sapiens
MDC-3100 competitive inhibitor Homo sapiens
NVP-AUY922 competitive inhibitor Homo sapiens
retaspimycin hydrochloride competitive inhibitor Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Homo sapiens 5829
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
180000
-
 gel filtration Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + H2O Homo sapiens
-
 ADP + phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P07900 and P08238 alpha and beta subunit
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O
-
 Homo sapiens ADP + phosphate
-
 ?

Subunits

Subunits Comment Organism
homodimer 2 * 90000, SDS-PAGE Homo sapiens

Synonyms

Synonyms Comment Organism
Hsp90 molecular chaperone
-
 Homo sapiens
HtpG
-
 Homo sapiens

General Information

General Information Comment Organism
metabolism the enzyme is implicated in the assembly of EPK protein kinases, bHlH transcription factors, nuclear hormone receptors, SCF ubiquitin ligases, RNA polymerases, PI3-kinase-like kinases such as mTOR and SMG1, snoRNPs8 and Nod-like innate immunity receptors Homo sapiens