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Literature summary for 3.6.4.10 extracted from
- Interaction of substrate-mimicking peptides with the AAA+ ATPase ClpB from Escherichia coli (2018), Arch. Biochem. Biophys., 655, 12-17 .
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| E279Q/E678Q | ATP-hydrolysis deficient substrate-trapping variant | Escherichia coli |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 570000 | - |
gel filtration | Escherichia coli |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + H2O | Escherichia coli | - |
ADP + phosphate | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Escherichia coli | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + H2O | - |
Escherichia coli | ADP + phosphate | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| hexamer | - |
Escherichia coli |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| AAA+ ATPase | - |
Escherichia coli |
| ClpB | - |
Escherichia coli |
General Information
| General Information | Comment | Organism |
|---|---|---|
| metabolism | the enzyme ClpB disaggregates and reactivates aggregated proteins in cooperation with the Hsp70/Hsp40 chaperones DnaK, DnaJ, and GrpE. The substrate recognition mechanism of ClpB relies on global surface properties of aggregated proteins | Escherichia coli |
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Release 2023.1 (January 2023)
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