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Literature summary for 3.6.4.10 extracted from

  • Gao, X.C.; Zhou, C.J.; Zhou, Z.R.; Wu, M.; Cao, C.Y.; Hu, H.Y.
    The C-terminal helices of heat shock protein 70 are essential for J-domain binding and ATPase activation (2012), J. Biol. Chem., 287, 6044-6052.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.6.4.10

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information in vitro studies demonstrate that the N terminus of HSP70 including the ATPase domain and the substrate-binding beta-subdomain is not sufficient to bind with the J domain of HSJ1a. The C-terminal helical alpha-subdomain of HSP70 (residues 562–610), is crucial for binding with the J domain of HSJ1a and stimulating the ATPase activity of HSP70 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O
-
 Homo sapiens ADP + phosphate
-
 ?

Synonyms

Synonyms Comment Organism
Hsp70
-
 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7
-
 assay at Homo sapiens