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Literature summary for 3.6.4.10 extracted from

  • Sriram, M.; Osipiuk, J.; Freeman, B.C.; Morimoto, R.I.; Joachimiak, A.
    Human Hsp70 molecular chaperone binds two calcium ions within the ATPase domain (1997), Structure, 5, 403-414.
    View publication on PubMed

Crystallization (Commentary)

Crystallization (Comment) Organism
41.9-kDa human Hsp70 ATPase domain Homo sapiens
44-kDa wild-type Hsc70 ATPase fragment Bos taurus
DnaK Escherichia coli

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
44000
-
-
Bos taurus
44000
-
N-terminal domain Homo sapiens
70000
-
-
Escherichia coli
70000
-
-
Homo sapiens
70000
-
-
Bos taurus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + H2O Escherichia coli
-
ADP + phosphate
-
?
ATP + H2O Homo sapiens
-
ADP + phosphate
-
?
ATP + H2O Bos taurus
-
ADP + phosphate
-
?

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-
Escherichia coli
-
-
-
Homo sapiens
-
human
-

Reaction

Reaction Comment Organism Reaction ID
ATP + H2O = ADP + phosphate highly diverse group of enzymes that perform many functions that are similar to those of chaperonins. They comprise a number of heat-shock-cognate proteins. They are also active in clathrin uncoating and in the oligomerization of actin Escherichia coli
ATP + H2O = ADP + phosphate highly diverse group of enzymes that perform many functions that are similar to those of chaperonins. They comprise a number of heat-shock-cognate proteins. They are also active in clathrin uncoating and in the oligomerization of actin Homo sapiens
ATP + H2O = ADP + phosphate highly diverse group of enzymes that perform many functions that are similar to those of chaperonins. They comprise a number of heat-shock-cognate proteins. They are also active in clathrin uncoating and in the oligomerization of actin Bos taurus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O
-
Escherichia coli ADP + phosphate
-
?
ATP + H2O
-
Homo sapiens ADP + phosphate
-
?
ATP + H2O
-
Bos taurus ADP + phosphate
-
?

Subunits

Subunits Comment Organism
dimer
-
Escherichia coli
dimer
-
Homo sapiens
dimer
-
Bos taurus

Synonyms

Synonyms Comment Organism
bATPase
-
Bos taurus
BiP
-
Bos taurus
Grp78
-
Bos taurus
hATPase
-
Homo sapiens
Hsc70
-
Bos taurus
human Hsp70 molecular chaperone
-
Homo sapiens