Cloned (Comment) | Organism |
---|---|
gene ENPP1, recombinant expression in COS-7 cells | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(3,5-dimethyl-1H-pyrazol-1-yl) (m-tolyl)methanone | - |
Homo sapiens | |
(3,5-dimethyl-1H-pyrazol-1-yl) (naphthalen-2-yl)methanone | - |
Homo sapiens | |
(3,5-dimethyl-1H-pyrazol-1-yl) (o-tolyl)methanone | - |
Homo sapiens | |
(3,5-dimethyl-1H-pyrazol-1-yl) (pyridin-4-yl)methanone | - |
Homo sapiens | |
(4-aminophenyl) (3,5-dimethyl-1H-pyrazol-1-yl)methanone | - |
Homo sapiens | |
(4-aminophenyl) (3,5-dimethyl-4-(p-tolyloxy)-1H-pyrazol-1-yl)methanone | - |
Homo sapiens | |
(4-aminophenyl) (4-chloro-3,5-dimethyl-1H-pyrazol-1-yl)methanone | - |
Homo sapiens | |
(4-chloro-3,5-dimethyl-1H-pyrazol-1-yl) (4-chlorophenyl)methanone | - |
Homo sapiens | |
(4-chloro-3,5-dimethyl-1H-pyrazol-1-yl) (m-tolyl)methanone | - |
Homo sapiens | |
(4-chloro-3,5-dimethyl-1H-pyrazol-1-yl) (naphthalen-2-yl)methanone | - |
Homo sapiens | |
(4-chloro-3,5-dimethyl-1H-pyrazol-1-yl) (o-tolyl)methanone | - |
Homo sapiens | |
(4-chloro-3,5-dimethyl-1H-pyrazol-1-yl) (p-tolyl)methanone | - |
Homo sapiens | |
(4-chloro-3,5-dimethyl-1H-pyrazol-1-yl) (pyridin-4-yl)methanone | - |
Homo sapiens | |
(4-chlorophenyl) (3,5-dimethyl-1H-pyrazol-1-yl)methanone | - |
Homo sapiens | |
(4-chlorophenyl) (3,5-dimethyl-4-(p-tolyloxy)-1H-pyrazol-1-yl)methanone | - |
Homo sapiens | |
(E)-1-(4-chloro-3,5-dimethyl-1H-pyrazol-1-yl)-3-phenylprop-2-en-1-one | - |
Homo sapiens | |
(R)-1-(4-chloro-3,5-dimethyl-1H-pyrazol-1-yl)-2-(4-isobutylphenyl)propan-1-one | - |
Homo sapiens | |
1-(4-aminobenzoyl)-5-methyl-1H-pyrazol-3(2H)-one | - |
Homo sapiens | |
3,5-dimethyl-4-(naphthalen-2-yloxy)-1H-pyrazole | - |
Homo sapiens | |
3,8-dibromo-2-(trifluoromethyl)quinolin-4(1H)-one | - |
Homo sapiens | |
3-chloropentane-2,4-dione | - |
Homo sapiens | |
3-methyl-2-(4-methylbenzoyl)-1,2-dihydropyrazol-5-one | - |
Homo sapiens | |
ethyl 3-oxobutanoate | - |
Homo sapiens | |
additional information | synthesis, alkaline phosphatase, nucleotide pyrophosphatase/phosphodiesterase and nucleoside triphosphate diphosphohydrolase inhibition studies with potential anticancer profile, structure activity and structure selectivity relationship of 2-benzoyl-5-methyl-1H-pyrazol-3(2H)-one derivatives, overview. The cytotoxic potential of the synthesized pyrazole derivatives is scrutinized against three different cancer cell lines i.e. breast cancer cells (MCF-7), cervical cancer cells (HeLa), and bone marrow lymphoblast cells (K-562). The assay is performed by using MTT (dimethyl-2-thiazolyl-2,5-diphenyl-2H-tetrazolium bromide)-based cell viability assay; synthesis, alkaline phosphatase, nucleotide pyrophosphatase/phosphodiesterase and nucleoside triphosphate diphosphohydrolase inhibition studies with potential anticancer profile, structure activity and structure selectivity relationship of 2-benzoyl-5-methyl-1H-pyrazol-3(2H)-one derivatives, overview. The cytotoxic potential of the synthesized pyrazole derivatives is scrutinized against three different cancer cell lines i.e. breast cancer cells (MCF-7), cervical cancer cells (HeLa), and bone marrow lymphoblast cells (K-562). The assay is performed by using MTT (dimethyl-2-thiazolyl-2,5-diphenyl-2H-tetrazolium bromide)-based cell viability assay | Homo sapiens | |
Pentane-2,4-dione | - |
Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
extracellular | - |
Homo sapiens | - |
- |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | O14638 | - |
- |
Homo sapiens | P22413 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HeLa cell | - |
Homo sapiens | - |
K-562 cell | - |
Homo sapiens | - |
MCF-7 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
4-nitrophenyl 5'-thymidine monophosphate + H2O | - |
Homo sapiens | 4-nitrophenol + 5'-thymidine monophosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
h-NPP1 | - |
Homo sapiens |
h-NPP3 | - |
Homo sapiens |
NPP1 | - |
Homo sapiens |
NPP3 | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
9.5 | - |
assay at | Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.00032 | - |
pH 9.5, 37°C, NPP3 | Homo sapiens | (4-chloro-3,5-dimethyl-1H-pyrazol-1-yl) (o-tolyl)methanone | |
0.00035 | - |
pH 9.5, 37°C, NPP3 | Homo sapiens | (3,5-dimethyl-1H-pyrazol-1-yl) (pyridin-4-yl)methanone | |
0.00041 | - |
pH 9.5, 37°C, NPP3 | Homo sapiens | 1-(4-aminobenzoyl)-5-methyl-1H-pyrazol-3(2H)-one | |
0.00051 | - |
pH 9.5, 37°C, NPP3 | Homo sapiens | (4-aminophenyl) (3,5-dimethyl-4-(p-tolyloxy)-1H-pyrazol-1-yl)methanone | |
0.00063 | - |
pH 9.5, 37°C, NPP1 | Homo sapiens | 3,8-dibromo-2-(trifluoromethyl)quinolin-4(1H)-one | |
0.00063 | - |
pH 9.5, 37°C, NPP3 | Homo sapiens | (4-chloro-3,5-dimethyl-1H-pyrazol-1-yl) (4-chlorophenyl)methanone | |
0.00115 | - |
pH 9.5, 37°C, NPP3 | Homo sapiens | (4-chlorophenyl) (3,5-dimethyl-1H-pyrazol-1-yl)methanone | |
0.00122 | - |
pH 9.5, 37°C, NPP3 | Homo sapiens | (4-aminophenyl) (4-chloro-3,5-dimethyl-1H-pyrazol-1-yl)methanone | |
0.00126 | - |
pH 9.5, 37°C, NPP3 | Homo sapiens | 3,5-dimethyl-4-(naphthalen-2-yloxy)-1H-pyrazole | |
0.00126 | - |
pH 9.5, 37°C, NPP3 | Homo sapiens | 3-methyl-2-(4-methylbenzoyl)-1,2-dihydropyrazol-5-one | |
0.00153 | - |
pH 9.5, 37°C, NPP3 | Homo sapiens | (4-chloro-3,5-dimethyl-1H-pyrazol-1-yl) (m-tolyl)methanone | |
0.00181 | - |
pH 9.5, 37°C, NPP3 | Homo sapiens | (3,5-dimethyl-1H-pyrazol-1-yl) (naphthalen-2-yl)methanone | |
0.00225 | - |
pH 9.5, 37°C, NPP3 | Homo sapiens | (E)-1-(4-chloro-3,5-dimethyl-1H-pyrazol-1-yl)-3-phenylprop-2-en-1-one | |
0.00226 | - |
pH 9.5, 37°C, NPP3 | Homo sapiens | (4-chloro-3,5-dimethyl-1H-pyrazol-1-yl) (naphthalen-2-yl)methanone | |
0.00237 | - |
pH 9.5, 37°C, NPP3 | Homo sapiens | (4-chlorophenyl) (3,5-dimethyl-4-(p-tolyloxy)-1H-pyrazol-1-yl)methanone | |
0.00253 | - |
pH 9.5, 37°C, NPP1 | Homo sapiens | (4-chlorophenyl) (3,5-dimethyl-4-(p-tolyloxy)-1H-pyrazol-1-yl)methanone | |
0.00315 | - |
pH 9.5, 37°C, NPP3 | Homo sapiens | (4-aminophenyl) (3,5-dimethyl-1H-pyrazol-1-yl)methanone | |
0.00322 | - |
pH 9.5, 37°C, NPP3 | Homo sapiens | (3,5-dimethyl-1H-pyrazol-1-yl) (m-tolyl)methanone | |
0.00342 | - |
pH 9.5, 37°C, NPP3 | Homo sapiens | (3,5-dimethyl-1H-pyrazol-1-yl) (o-tolyl)methanone | |
0.00435 | - |
pH 9.5, 37°C, NPP1 | Homo sapiens | (4-aminophenyl) (4-chloro-3,5-dimethyl-1H-pyrazol-1-yl)methanone | |
0.00534 | - |
pH 9.5, 37°C, NPP1 | Homo sapiens | (4-chloro-3,5-dimethyl-1H-pyrazol-1-yl) (4-chlorophenyl)methanone | |
0.00542 | - |
pH 9.5, 37°C, NPP1 | Homo sapiens | (4-chloro-3,5-dimethyl-1H-pyrazol-1-yl) (pyridin-4-yl)methanone | |
0.00598 | - |
pH 9.5, 37°C, NPP3 | Homo sapiens | (4-chloro-3,5-dimethyl-1H-pyrazol-1-yl) (pyridin-4-yl)methanone | |
0.00804 | - |
pH 9.5, 37°C, NPP1 | Homo sapiens | 3,5-dimethyl-4-(naphthalen-2-yloxy)-1H-pyrazole | |
0.0124 | - |
pH 9.5, 37°C, NPP3 | Homo sapiens | (R)-1-(4-chloro-3,5-dimethyl-1H-pyrazol-1-yl)-2-(4-isobutylphenyl)propan-1-one | |
0.1 | - |
pH 9.5, 37°C, NPP1 | Homo sapiens | (3,5-dimethyl-1H-pyrazol-1-yl) (m-tolyl)methanone | |
0.1 | - |
pH 9.5, 37°C, NPP1 | Homo sapiens | (3,5-dimethyl-1H-pyrazol-1-yl) (naphthalen-2-yl)methanone | |
0.1 | - |
pH 9.5, 37°C, NPP1 | Homo sapiens | (3,5-dimethyl-1H-pyrazol-1-yl) (o-tolyl)methanone | |
0.1 | - |
pH 9.5, 37°C, NPP1 | Homo sapiens | (3,5-dimethyl-1H-pyrazol-1-yl) (pyridin-4-yl)methanone | |
0.1 | - |
pH 9.5, 37°C, NPP1 | Homo sapiens | (4-aminophenyl) (3,5-dimethyl-1H-pyrazol-1-yl)methanone | |
0.1 | - |
pH 9.5, 37°C, NPP1 | Homo sapiens | (4-aminophenyl) (3,5-dimethyl-4-(p-tolyloxy)-1H-pyrazol-1-yl)methanone | |
0.1 | - |
pH 9.5, 37°C, NPP1 | Homo sapiens | (4-chloro-3,5-dimethyl-1H-pyrazol-1-yl) (m-tolyl)methanone | |
0.1 | - |
pH 9.5, 37°C, NPP1 | Homo sapiens | (4-chloro-3,5-dimethyl-1H-pyrazol-1-yl) (naphthalen-2-yl)methanone | |
0.1 | - |
pH 9.5, 37°C, NPP1 | Homo sapiens | (4-chloro-3,5-dimethyl-1H-pyrazol-1-yl) (o-tolyl)methanone | |
0.1 | - |
pH 9.5, 37°C, NPP1 | Homo sapiens | (4-chloro-3,5-dimethyl-1H-pyrazol-1-yl) (p-tolyl)methanone | |
0.1 | - |
pH 9.5, 37°C, NPP1 | Homo sapiens | (4-chlorophenyl) (3,5-dimethyl-1H-pyrazol-1-yl)methanone | |
0.1 | - |
pH 9.5, 37°C, NPP1 | Homo sapiens | (E)-1-(4-chloro-3,5-dimethyl-1H-pyrazol-1-yl)-3-phenylprop-2-en-1-one | |
0.1 | - |
pH 9.5, 37°C, NPP1 | Homo sapiens | (R)-1-(4-chloro-3,5-dimethyl-1H-pyrazol-1-yl)-2-(4-isobutylphenyl)propan-1-one | |
0.1 | - |
pH 9.5, 37°C, NPP1 | Homo sapiens | 1-(4-aminobenzoyl)-5-methyl-1H-pyrazol-3(2H)-one | |
0.1 | - |
pH 9.5, 37°C, NPP1 | Homo sapiens | 3-methyl-2-(4-methylbenzoyl)-1,2-dihydropyrazol-5-one | |
0.23 | - |
pH 9.5, 37°C, NPP3 | Homo sapiens | (4-chloro-3,5-dimethyl-1H-pyrazol-1-yl) (p-tolyl)methanone |
General Information | Comment | Organism |
---|---|---|
physiological function | NPP1 is associated with the regulation of extracellular diphosphate levels | Homo sapiens |