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Literature summary for 3.6.1.9 extracted from

  • Fuerstenau, C.R.; Trentin, D.d.S.; Barreto-Chaves, M.L.; Sarkis, J.J.
    Ecto-nucleotide pyrophosphatase/phosphodiesterase as part of a multiple system for nucleotide hydrolysis by platelets from rats: kinetic characterization and biochemical properties (2006), Platelets, 17, 84-91.
    View publication on PubMed
Search for more literature for 3.6.1.9

Inhibitors

Inhibitors Comment Organism Structure
AMP 0.5 mM, inhibition Rattus norvegicus
EDTA 0.1 mM, complete inhibition Rattus norvegicus
L-phenylalanine 5 mM, 10% loss of activity Rattus norvegicus
suramin 0.25 mM, inhibition Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.106
-
 p-nitrophenyl 5'-thymidine monophosphate pH 8.9, 37°C Rattus norvegicus

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ great stimulation Rattus norvegicus
Mg2+ slight stimulation Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
blood platelet colocalization of enzyme with an ecto-nucleoside triphosphate diphosphohydrolase and an ecto-5’-nucleotidase on platelet surface Rattus norvegicus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2894
-
 pH 8.9, 37°C, intact platelet preparation Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
p-nitrophenyl 5'-thymidine monophosphate + H2O
-
 Rattus norvegicus 4-nitrophenol + TMP
-
 ?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8.5 8.9
-
 Rattus norvegicus