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Literature summary for 3.6.1.9 extracted from

  • Gijsbers, R.; Ceulemans, H.; Bollen, M.
    Functional characterization of the non-catalytic ectodomains of the nucleotide pyrophosphatase/phosphodiesterase NPP1 (2003), Biochem. J., 371, 321-330.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
wild-type enzyme NPP1 and NPP1-DELTA804-905 is expressed in COS cells as fusions with enhanced green fluorescent protein Mus musculus

Protein Variants

Protein Variants Comment Organism
DELTA804-905 mutation results in complete loss of activity, protein remains entirely intracellular Mus musculus
K173Q polymorphisms of NPP1 is associated with the aetiology of insulin resistance, does not affect the dimerization or catalytic activity of NPP1 and does not endow NPP1 with an affinity for the insulin receptor Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
plasma membrane
-
Mus musculus 5886
-

Organism

Organism UniProt Comment Textmining
Mus musculus P06802 expressed as haemagglutinin-tagged fusion protein in COS-1 cells or HeLa cells
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
p-nitrophenyl thymidine 5'-monophosphate + H2O
-
Mus musculus ?
-
?

Synonyms

Synonyms Comment Organism
nucleotide pyrophosphatase/phosphodiesterase NPP1
-
Mus musculus