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Literature summary for 3.6.1.9 extracted from

  • Rossomando, E.F.; Hodge Jahngen, J.
    Solubilization and substrate specificity of membrane-bound nucleotide phosphodiesterase-pyrophosphohydrolase activities from Dictyostelium discoideum (1983), J. Biol. Chem., 258, 7653-7660.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
Adenyl-5'-yl imidodiphosphate competitive inhibition of formycin 5'-triphosphate hydrolysis, Ki: 0.22 mM Dictyostelium discoideum
ATP competitive inhibition of formycin 5'-triphosphate hydrolysis, Ki: 0.1 mM Dictyostelium discoideum
beta,gamma-methyleneadenosine 5'-triphosphate competitive inhibition of formycin 5'-triphosphate hydrolysis, Ki: 0.1 mM Dictyostelium discoideum

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.055
-
ATP
-
Dictyostelium discoideum
0.1
-
Formycin 5'-triphosphate
-
Dictyostelium discoideum
0.1
-
5'-adenylylimidodiphosphate
-
Dictyostelium discoideum
0.1
-
AMPPCP
-
Dictyostelium discoideum
0.8
-
UDP-N-acetyl-alpha-D-glucosamine
-
Dictyostelium discoideum

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
Dictyostelium discoideum 16020
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mn2+ required for maximal activity Dictyostelium discoideum

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + H2O Dictyostelium discoideum
-
AMP + diphosphate ADP formation as a result of adenylate kinase activity ?
GDP-mannose + H2O Dictyostelium discoideum
-
GMP + D-mannose-1-phosphate
-
?
UDP-glucuronic acid + H2O Dictyostelium discoideum
-
UMP + glucuronic acid phosphate
-
?
UDP-N-acetyl-alpha-D-glucosamine + H2O Dictyostelium discoideum
-
UMP + N-acetyl-alpha-D-glucosaminyl-1-phosphate
-
?

Organism

Organism UniProt Comment Textmining
Dictyostelium discoideum
-
-
-

Purification (Commentary)

Purification (Comment) Organism
partial Dictyostelium discoideum

Source Tissue

Source Tissue Comment Organism Textmining
cell culture
-
Dictyostelium discoideum
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5'-adenylylimidodiphosphate + H2O
-
Dictyostelium discoideum ?
-
?
5'-deoxy-5'-thioadenosine 5'-triphosphate + H2O
-
Dictyostelium discoideum 5'-deoxy-5'-thioadenosine 3'-monophosphate + phosphate
-
?
adenosine 5'-O-(2-thiotriphosphate) + H2O
-
Dictyostelium discoideum AMP + ?
-
?
adenosine 5'-O-(3-thiotriphosphate) + H2O
-
Dictyostelium discoideum AMP + ?
-
?
ATP + H2O
-
Dictyostelium discoideum AMP + diphosphate ADP formation as a result of adenylate kinase activity ?
beta,gamma-methyleneadenosine 5'-triphosphate + H2O
-
Dictyostelium discoideum adenosine 5'-monophosphate + phosphomethylposphoric acid
-
?
formycin 5'-triphosphate + H2O
-
Dictyostelium discoideum ?
-
?
GDP-mannose + H2O
-
Dictyostelium discoideum GMP + D-mannose-1-phosphate
-
?
UDP-glucuronic acid + H2O
-
Dictyostelium discoideum UMP + glucuronic acid phosphate
-
?
UDP-N-acetyl-alpha-D-glucosamine + H2O
-
Dictyostelium discoideum UMP + N-acetyl-alpha-D-glucosaminyl-1-phosphate
-
?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
45
-
-
Dictyostelium discoideum

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7
-
-
Dictyostelium discoideum

pH Stability

pH Stability pH Stability Maximum Comment Organism
8
-
minimal activity above Dictyostelium discoideum

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.1
-
beta,gamma-methyleneadenosine 5'-triphosphate competitive inhibition of formycin 5'-triphosphate hydrolysis Dictyostelium discoideum