Studies on a Ca2+-dependent nucleoside triphosphate pyrophosphohydrolase in rat liver plasma membranes

Torp-Pedersen, C.; Flodgaard, H.; Saermark, T.; Biochim. Biophys. Acta 571, 94-104 (1979)

Data extracted from this reference:

Inhibitors

Commentary

Organism

Structure

GMP

competitive inhibition with Ki: 0.001 mM

Rattus norvegicus

UDPGlc

very weak

Rattus norvegicus

KM Value [mM]

KM Value Maximum [mM]

Substrate

Commentary

Organism

Structure

0.00032

-

ATP

with 0.1 mM free Ca2+, pH 8

Rattus norvegicus

0.0022

-

GTP

with 0.1 mM free Ca2+, pH 8

Rattus norvegicus

Metals/Ions

Commentary

Organism

Structure

Ba2+

weak activation

Rattus norvegicus

Ca2+

required for activity

Rattus norvegicus

Mg2+

weak activation

Rattus norvegicus

Sr2+

weak activation

Rattus norvegicus

Natural Substrates

Organism

Commentary (Nat. Sub.)

Natural Products

Commentary (Nat. Pro.)

Organism (Nat. Pro.)

Reversibility

ID

ATP + H2O

Rattus norvegicus

-

AMP + diphosphate

-

Rattus norvegicus

?

CTP + H2O

Rattus norvegicus

-

CMP + diphosphate

-

Rattus norvegicus

?

Substrates

Commentary Substrates

Literature (Substrates)

Organism

Products

Commentary (Products)

Literature (Products)

Organism (Products)

Reversibility

Substrate Product ID

ATP + H2O

-

210225

Rattus norvegicus

AMP + diphosphate

-

210225

Rattus norvegicus

?

CTP + H2O

-

210225

Rattus norvegicus

CMP + diphosphate

-

210225

Rattus norvegicus

?

dATP + H2O

-

210225

Rattus norvegicus

dAMP + diphosphate

-

210225

Rattus norvegicus

?

GTP + H2O

-

210225

Rattus norvegicus

GMP + diphosphate

-

-

-

-

Ki Value [mM]

Ki Value maximum [mM]

Inhibitor

Commentary

Organism

Structure

0.001

-

GMP

competitive inhibition

Rattus norvegicus

Inhibitors

Commentary

Organism

Structure

GMP

competitive inhibition with Ki: 0.001 mM

Rattus norvegicus

UDPGlc

very weak

Rattus norvegicus

Ki Value [mM]

Ki Value maximum [mM]

Inhibitor

Commentary

Organism

Structure

0.001

-

GMP

competitive inhibition

Rattus norvegicus

KM Value [mM]

KM Value Maximum [mM]

Substrate

Commentary

Organism

Structure

0.00032

-

ATP

with 0.1 mM free Ca2+, pH 8

Rattus norvegicus

0.0022

-

GTP

with 0.1 mM free Ca2+, pH 8

Rattus norvegicus

Metals/Ions

Commentary

Organism

Structure

Ba2+

weak activation

Rattus norvegicus

Ca2+

required for activity

Rattus norvegicus

Mg2+

weak activation

Rattus norvegicus

Sr2+

weak activation

Rattus norvegicus

Natural Substrates

Organism

Commentary (Nat. Sub.)

Natural Products

Commentary (Nat. Pro.)

Organism (Nat. Pro.)

Reversibility

ID

ATP + H2O

Rattus norvegicus

-

AMP + diphosphate

-

Rattus norvegicus

?

CTP + H2O

Rattus norvegicus

-

CMP + diphosphate

-

Rattus norvegicus

?

Substrates

Commentary Substrates

Literature (Substrates)

Organism

Products

Commentary (Products)

Literature (Products)

Organism (Products)

Reversibility

ID

ATP + H2O

-

210225

Rattus norvegicus

AMP + diphosphate

-

210225

Rattus norvegicus

?

CTP + H2O

-

210225

Rattus norvegicus

CMP + diphosphate

-

210225

Rattus norvegicus

?

dATP + H2O

-

210225

Rattus norvegicus

dAMP + diphosphate

-

210225

Rattus norvegicus

?

GTP + H2O

-

210225

Rattus norvegicus

GMP + diphosphate

-

-

-

-

No.

1st author

Pub Med

title

organims

journal

volume

pages

year

Activating Compound

Application

Cloned(Commentary)

Crystallization (Commentary)

Engineering

General Stability

Inhibitors

KM Value [mM]

Localization

Metals/Ions

Molecular Weight [Da]

Natural Substrates/ Products (Substrates)

Organic Solvent Stability

Organism

Oxidation Stability

Posttranslational Modification

Purification (Commentary)

Reaction

Renatured (Commentary)

Source Tissue

Specific Activity [micromol/min/mg]

Storage Stability

Substrates and Products (Substrate)

Subunits

Synonyms

Temperature Optimum [°C]

Temperature Range [°C]

Temperature Stability [°C]

Turnover Number [1/s]

pH Optimum

pH Range

pH Stability

Cofactor

Ki Value [mM]

pI Value

IC50 Value

Activating Compound (protein specific)

Application (protein specific)

Cloned(Commentary) (protein specific)

Cofactor (protein specific)

Crystallization (Commentary) (protein specific)

Engineering (protein specific)

General Stability (protein specific)

IC50 Value (protein specific)

Inhibitors (protein specific)

Ki Value [mM] (protein specific)

KM Value [mM] (protein specific)

Localization (protein specific)

Metals/Ions (protein specific)

Molecular Weight [Da] (protein specific)

Natural Substrates/ Products (Substrates) (protein specific)

Organic Solvent Stability (protein specific)

Oxidation Stability (protein specific)

Posttranslational Modification (protein specific)

Purification (Commentary) (protein specific)

Renatured (Commentary) (protein specific)

Source Tissue (protein specific)

Specific Activity [micromol/min/mg] (protein specific)

Storage Stability (protein specific)

Substrates and Products (Substrate) (protein specific)

Subunits (protein specific)

Temperature Optimum [°C] (protein specific)

Temperature Range [°C] (protein specific)

Temperature Stability [°C] (protein specific)

Turnover Number [1/s] (protein specific)

pH Optimum (protein specific)

pH Range (protein specific)

pH Stability (protein specific)

pI Value (protein specific)

Expression

General Information

General Information (protein specific)

Expression (protein specific)

KCat/KM [mM/s]

KCat/KM [mM/s] (protein specific)

668024

Martins

Inhibition of the ecto-ATPdiph ...

Schistosoma mansoni

Biosci. Rep.

20

369-381

2000

-

-

-

-

-

-

10

1

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1

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1

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2

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1

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10

1

1

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1

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-

-

-

-

-

-

-

-

-

-

726055

Rashid

Characterization of a RecA/RAD ...

Thermococcus kodakarensis

Nucleic Acids Res.

25

719-726

1997

-

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1

-

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2

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4

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1

1

1

-

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1

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-

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-

-

-

-

210227

Masuda

A unique ectonucleotide pyroph ...

Sus scrofa

J. Clin. Invest.

95

699-704

1995

-

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2

2

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2

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2

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1

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1

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1

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1

-

-

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-

-

-

-

-

-

210226

Capito

Presence of ATP-pyrophosphohyd ...

Mus musculus

Diabetes

35

1096-1100

1986

6

-

-

-

-

-

1

3

-

7

-

1

-

1

-

-

-

-

-

1

-

-

1

-

-

-

-

-

-

-

-

-

-

-

-

-

6

-

-

-

-

-

-

-

1

-

3

-

7

-

1

-

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-

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-

1

-

-

1

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

210225

Torp-Pedersen

Studies on a Ca2+-dependent nu ...

Rattus norvegicus

Biochim. Biophys. Acta

571

94-104

1979

-

-

-

-

-

-

2

2

1

4

1

2

-

2

-

-

-

-

-

3

-

-

4

-

-

-

-

-

-

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1

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2

1

2

1

4

1

2

-

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-

3

-

-

4

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

210224

Flodgaard

A calcium ion-dependent adenos ...

Rattus norvegicus

Biochem. J.

171

817-820

1978

-

-

-

-

-

-

-

-

1

4

-

1

-

2

-

-

1

-

-

2

1

-

3

-

-

-

-

-

-

-

-

-

-

-

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-

-

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-

-

1

4

-

1

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1

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2

1

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3

-

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-

-

-

-

-

-

-

-

-

-

-

-

210223

Kawamura

Change in ATP-pyrophosphohydro ...

Physarum polycephalum

Biochim. Biophys. Acta

421

195-202

1976

-

-

-

-

-

-

2

-

-

-

-

1

-

2

-

-

1

-

-

1

-

-

1

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-

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-

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-

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-

-

-

-

-

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2

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-

-

1

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1

-

1

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-

1

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-

-

-

-

-

-

-

-

-

-

-

210222

Kawamura

A calcium ion-dependent ATP py ...

Physarum polycephalum

Biochim. Biophys. Acta

397

207-219

1975

-

-

-

-

-

-

1

1

-

8

2

3

-

3

-

-

-

-

-

1

-

-

4

1

-

-

-

-

-

1

-

-

-

-

-

-

-

-

-

-

-

-

-

-

1

-

1

-

8

2

3

-

-

-

-

-

1

-

-

4

1

-

-

-

-

1

-

-

-

-

-

-

-

-

-

210221

Heppel

Mechanism of enzymatic hydroly ...

Bos taurus, Crotalus adamanteus, Oryctolagus cuniculus, Rattus norvegicus

J. Biol. Chem.

202

217-226

1953

-

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4

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5

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4

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1

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5

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1

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