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Literature summary for 3.6.1.8 extracted from
- A calcium ion-dependent ATP pyrophosphohydrolase in Physarum polycephalum (1975), Biochim. Biophys. Acta, 397, 207-219.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Caffeine | 25% inhibition at 3 mM | Physarum polycephalum |  |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 2 | - |
ATP | - |
Physarum polycephalum | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Ba2+ | no effect | Physarum polycephalum | |
| Ca2+ | required for activity | Physarum polycephalum | |
| Cd2+ | no effect | Physarum polycephalum | |
| Co2+ | no effect | Physarum polycephalum | |
| Cu2+ | no effect | Physarum polycephalum | |
| Mg2+ | weak activation | Physarum polycephalum | |
| Mn2+ | no effect | Physarum polycephalum | |
| Sr2+ | partial substitution for Ca2+ | Physarum polycephalum | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 56000 | - |
SDS-PAGE | Physarum polycephalum |
| 240000 | - |
gel filtration | Physarum polycephalum |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + H2O | Physarum polycephalum | - |
AMP + diphosphate | - |
? | |
| GTP + H2O | Physarum polycephalum | - |
GMP + diphosphate | - |
? | |
| ITP + H2O | Physarum polycephalum | - |
IMP + diphosphate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Physarum polycephalum | - |
acellular slime mold | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| plasmodium | - |
Physarum polycephalum | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + H2O | - |
Physarum polycephalum | AMP + diphosphate | - |
? | |
| beta,gamma-methylene ATP + H2O | - |
Physarum polycephalum | AMP + methylene diphosphate | - |
? | |
| GTP + H2O | - |
Physarum polycephalum | GMP + diphosphate | - |
? | |
| ITP + H2O | - |
Physarum polycephalum | IMP + diphosphate | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| tetramer | 4 * 56000, SDS-PAGE and gel filtration | Physarum polycephalum |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7 | - |
broad optimum range | Physarum polycephalum |
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Release 2023.1 (January 2023)
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