Crystallization (Comment) | Organism |
---|---|
aprataxin forkhead-associated domain and modeling of the pSDpTD peptide into the apo structure. pT recognition is provided by residues Arg29 and Ser41 | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
R29A | mutation of forkhead-associated domain residue, prevents its interaction with mediator of DNA-damage checkpoint protein MDC1 and recruitment to sites of DNA damage | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
nucleolus | aprataxin localizes at sites of DNA damage induced by high low linear energy transfer radiation | Homo sapiens | 5730 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q7Z2E3 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
fibroblast | - |
Homo sapiens | - |
HeLa cell | - |
Homo sapiens | - |
General Information | Comment | Organism |
---|---|---|
physiological function | aprataxin localizes at sites of DNA damage induced by high low linear energy transfer radiation and binds to mediator of DNA-damage checkpoint protein MDC1/NFBD1 through a phosphorylation-dependent interaction. This interaction is mediated via the aprataxin forkhead-associated domain and multiple casein kinase 2 diphosphorylated S-D-T-D motifs in MDC1 | Homo sapiens |