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Literature summary for 3.6.1.6 extracted from
- A putative adenosine kinase family protein possesses adenosine diphosphatase activity (2016), Biosci. Biotechnol. Biochem., 80, 2138-2143 .
Crystallization (Commentary)
| Crystallization (Comment) | Organism |
|---|---|
| crystal structure comparison of homologous structures of TTHA1091 protein (PDB ID 1VGG) and PAE2307 protein (PDB ID 1WVQ, from Pyrobaculum aerophilum strain ATCC 51768), overview | Thermus thermophilus |
| crystal structure comparison of homologous structures of TTHA1091 protein (PDB ID 1VGG, from Thermus thermophilus strain HB8) and PAE2307 protein (PDB ID 1WVQ), overview | Pyrobaculum aerophilum |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Ca2+ | about 90% inhibition at 10 mM | Thermus thermophilus |  |
| Mg2+ | complete inhibition at 10 mM | Thermus thermophilus | |
| Mn2+ | complete inhibition at 10 mM | Thermus thermophilus | |
| additional information | the ADPase activity is inhibited by divalent cations | Thermus thermophilus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ADP + H2O | Pyrobaculum aerophilum | - |
AMP + phosphate | - |
? | |
| ADP + H2O | Thermus thermophilus | - |
AMP + phosphate | - |
? | |
| ADP + H2O | Pyrobaculum aerophilum DSM 7523 | - |
AMP + phosphate | - |
? | |
| ADP + H2O | Pyrobaculum aerophilum IM2 | - |
AMP + phosphate | - |
? | |
| ADP + H2O | Thermus thermophilus DSM 579 | - |
AMP + phosphate | - |
? | |
| ADP + H2O | Pyrobaculum aerophilum NBRC 100827 | - |
AMP + phosphate | - |
? | |
| ADP + H2O | Pyrobaculum aerophilum ATCC 51768 | - |
AMP + phosphate | - |
? | |
| ADP + H2O | Pyrobaculum aerophilum JCM 9630 | - |
AMP + phosphate | - |
? | |
| ADP + H2O | Thermus thermophilus ATCC 27634 | - |
AMP + phosphate | - |
? | |
| CDP + H2O | Pyrobaculum aerophilum | - |
CMP + phosphate | - |
? | |
| CDP + H2O | Thermus thermophilus | - |
CMP + phosphate | - |
? | |
| CDP + H2O | Pyrobaculum aerophilum DSM 7523 | - |
CMP + phosphate | - |
? | |
| CDP + H2O | Pyrobaculum aerophilum IM2 | - |
CMP + phosphate | - |
? | |
| CDP + H2O | Pyrobaculum aerophilum NBRC 100827 | - |
CMP + phosphate | - |
? | |
| CDP + H2O | Pyrobaculum aerophilum ATCC 51768 | - |
CMP + phosphate | - |
? | |
| CDP + H2O | Pyrobaculum aerophilum JCM 9630 | - |
CMP + phosphate | - |
? | |
| additional information | Thermus thermophilus | the TTHA1091 protein does not possess ADK activity but instead possesses adenosine diphosphatase (ADPase) activity | ? | - |
- |
|
| additional information | Thermus thermophilus DSM 579 | the TTHA1091 protein does not possess ADK activity but instead possesses adenosine diphosphatase (ADPase) activity | ? | - |
- |
|
| additional information | Thermus thermophilus ATCC 27634 | the TTHA1091 protein does not possess ADK activity but instead possesses adenosine diphosphatase (ADPase) activity | ? | - |
- |
|
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Pyrobaculum aerophilum | Q8ZVF7 | - |
- |
| Pyrobaculum aerophilum ATCC 51768 | Q8ZVF7 | - |
- |
| Pyrobaculum aerophilum DSM 7523 | Q8ZVF7 | - |
- |
| Pyrobaculum aerophilum IM2 | Q8ZVF7 | - |
- |
| Pyrobaculum aerophilum JCM 9630 | Q8ZVF7 | - |
- |
| Pyrobaculum aerophilum NBRC 100827 | Q8ZVF7 | - |
- |
| Thermus thermophilus | Q5SJC3 | - |
- |
| Thermus thermophilus ATCC 27634 | Q5SJC3 | - |
- |
| Thermus thermophilus DSM 579 | Q5SJC3 | - |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ADP + H2O | - |
Pyrobaculum aerophilum | AMP + phosphate | - |
? | |
| ADP + H2O | - |
Thermus thermophilus | AMP + phosphate | - |
? | |
| ADP + H2O | best substrate | Thermus thermophilus | AMP + phosphate | - |
? | |
| ADP + H2O | - |
Pyrobaculum aerophilum DSM 7523 | AMP + phosphate | - |
? | |
| ADP + H2O | - |
Pyrobaculum aerophilum IM2 | AMP + phosphate | - |
? | |
| ADP + H2O | - |
Thermus thermophilus DSM 579 | AMP + phosphate | - |
? | |
| ADP + H2O | best substrate | Thermus thermophilus DSM 579 | AMP + phosphate | - |
? | |
| ADP + H2O | - |
Pyrobaculum aerophilum NBRC 100827 | AMP + phosphate | - |
? | |
| ADP + H2O | - |
Pyrobaculum aerophilum ATCC 51768 | AMP + phosphate | - |
? | |
| ADP + H2O | - |
Pyrobaculum aerophilum JCM 9630 | AMP + phosphate | - |
? | |
| ADP + H2O | - |
Thermus thermophilus ATCC 27634 | AMP + phosphate | - |
? | |
| ADP + H2O | best substrate | Thermus thermophilus ATCC 27634 | AMP + phosphate | - |
? | |
| CDP + H2O | - |
Pyrobaculum aerophilum | CMP + phosphate | - |
? | |
| CDP + H2O | - |
Thermus thermophilus | CMP + phosphate | - |
? | |
| CDP + H2O | higher activity | Thermus thermophilus | CMP + phosphate | - |
? | |
| CDP + H2O | - |
Pyrobaculum aerophilum DSM 7523 | CMP + phosphate | - |
? | |
| CDP + H2O | - |
Pyrobaculum aerophilum IM2 | CMP + phosphate | - |
? | |
| CDP + H2O | - |
Pyrobaculum aerophilum NBRC 100827 | CMP + phosphate | - |
? | |
| CDP + H2O | - |
Pyrobaculum aerophilum ATCC 51768 | CMP + phosphate | - |
? | |
| CDP + H2O | - |
Pyrobaculum aerophilum JCM 9630 | CMP + phosphate | - |
? | |
| dADP + H2O | very low activity | Thermus thermophilus | dAMP + phosphate | - |
? | |
| dGDP + H2O | very low activity | Thermus thermophilus | dGMP + phosphate | - |
? | |
| GDP + H2O | very low activity | Thermus thermophilus | GMP + phosphate | - |
? | |
| GDP + H2O | very low activity | Thermus thermophilus DSM 579 | GMP + phosphate | - |
? | |
| GDP + H2O | very low activity | Thermus thermophilus ATCC 27634 | GMP + phosphate | - |
? | |
| additional information | the TTHA1091 protein does not possess ADK activity but instead possesses adenosine diphosphatase (ADPase) activity | Thermus thermophilus | ? | - |
- |
|
| additional information | the enzyme encoded by TTHA1091 shows degradation of ADP to AMP and thus possesses adenosine diphosphatase (ADPase) activity, but it does not catalyse the phosphorylation of adenosine when ATP or ADP are used as phosphate donors. The ADPase activity is specific for ADP and CDP. No or poor activity with UDP, TDP, and dCDP, substrate specificity, overview | Thermus thermophilus | ? | - |
- |
|
| additional information | the TTHA1091 protein does not possess ADK activity but instead possesses adenosine diphosphatase (ADPase) activity | Thermus thermophilus DSM 579 | ? | - |
- |
|
| additional information | the enzyme encoded by TTHA1091 shows degradation of ADP to AMP and thus possesses adenosine diphosphatase (ADPase) activity, but it does not catalyse the phosphorylation of adenosine when ATP or ADP are used as phosphate donors. The ADPase activity is specific for ADP and CDP. No or poor activity with UDP, TDP, and dCDP, substrate specificity, overview | Thermus thermophilus DSM 579 | ? | - |
- |
|
| additional information | the TTHA1091 protein does not possess ADK activity but instead possesses adenosine diphosphatase (ADPase) activity | Thermus thermophilus ATCC 27634 | ? | - |
- |
|
| additional information | the enzyme encoded by TTHA1091 shows degradation of ADP to AMP and thus possesses adenosine diphosphatase (ADPase) activity, but it does not catalyse the phosphorylation of adenosine when ATP or ADP are used as phosphate donors. The ADPase activity is specific for ADP and CDP. No or poor activity with UDP, TDP, and dCDP, substrate specificity, overview | Thermus thermophilus ATCC 27634 | ? | - |
- |
|
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| adenosine diphosphatase | - |
Pyrobaculum aerophilum |
| adenosine diphosphatase | - |
Thermus thermophilus |
| ADPase | - |
Pyrobaculum aerophilum |
| ADPase | - |
Thermus thermophilus |
| PAE2307 | - |
Pyrobaculum aerophilum |
| TTHA1091 | - |
Thermus thermophilus |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 70 | - |
assay at | Thermus thermophilus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 8 | - |
assay at | Thermus thermophilus |
General Information
| General Information | Comment | Organism |
|---|---|---|
| evolution | the enzyme is a family member of the COG1839 family, defined as adenosine-specific kinase family based on structural analysis and the adenosine-binding ability | Pyrobaculum aerophilum |
| evolution | the enzyme is a family member of the COG1839 family, defined as adenosine-specific kinase family based on structural analysis and the adenosine-binding ability | Thermus thermophilus |
| additional information | structure comparison of homologous structures of TTHA1091 protein (PDB ID 1VGG) and PAE2307 protein (PDB ID 1WVQ, from Pyrobaculum aerophilum strain ATCC 51768), overview. The model structure also suggests that the beta-phosphate group of ADP (and CDP) can be located near His80 | Thermus thermophilus |
| additional information | structure comparison of homologous structures of TTHA1091 protein (PDB ID 1VGG, from Thermus thermophilus strain HB8) and PAE2307 protein (PDB ID 1WVQ), overview. The model structure also suggests that the beta-phosphate group of ADP (and CDP) can be located near His80 | Pyrobaculum aerophilum |
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Release 2023.1 (January 2023)
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