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Literature summary for 3.6.1.6 extracted from
- Ectonucleotidases in the digestive system: focus on NTPDase3 localization (2011), Am. J. Physiol. Gastrointest. Liver Physiol., 300, G608-G620.
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
- |
- |
| Mus musculus C57BL/6 | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| epithelial cell | - |
Mus musculus | - |
| esophagus | while all cell layers of the esophagus express NTPDase3, NTPDase3 localization in the forestomach is limited to the basal cell layer | Mus musculus | - |
| gastrointestinal tract | NTPDase3 in cells from the stratified esophageal and forestomach epithelia, and in some enteroendocrine cells of the gastric antrum. NTPDase3 and -2 are coexpressed within the myenteric and submucosal plexuses, as well as in the nerve terminals of the smooth muscle layer and mucosa | Mus musculus | - |
| additional information | specific localization of NTPDase3 in the digestive system, by semiquantitative RT-PCR, immunohistochemistry, and in situ activity assay, detailed overview | Mus musculus | - |
| pancreas | - |
Mus musculus | - |
| pancreatic acinar cell | - |
Mus musculus | - |
| parotid gland | serous acinar cells of parotid glands | Mus musculus | - |
| salivary gland | NTPDase3 in epithelial cells in serous acini of salivary glands and mucous acini and duct cells of sublingual salivary glands | Mus musculus | - |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| ecto-ATPase | - |
Mus musculus |
| NTPDase3 | - |
Mus musculus |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 25 | - |
assay at | Mus musculus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.4 | - |
assay at | Mus musculus |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | the mean glial Ca2+ response to ATP was significantly larger in the presence of an NTPDase inhibitor | Mus musculus |
| physiological function | functional roles of NTPDase3 in association with NTPDase2 and ecto-5'-nucleotidase, in epithelial functions such as secretion and in enteric neurotransmission | Mus musculus |
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Release 2023.1 (January 2023)
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