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Literature summary for 3.6.1.6 extracted from

  • Levesque, S.A.; Kukulski, F.; Enjyoji, K.; Robson, S.C.; Sevigny, J.
    NTPDase1 governs P2X7-dependent functions in murine macrophages (2010), Eur. J. Immunol., 40, 1473-1485.
    View publication on PubMedView publication on EuropePMC

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
macrophage
-
Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ADP + H2O
-
Mus musculus AMP + phosphate
-
?
ATP + H2O
-
Mus musculus ADP + phosphate
-
?

Synonyms

Synonyms Comment Organism
CD39
-
Mus musculus
NTPDase1
-
Mus musculus
nucleoside triphosphate diphosphohydrolase 1
-
Mus musculus

General Information

General Information Comment Organism
malfunction macrophages isolated from NTPDase1-null mice are devoid of all ADPase and most ATPase activities when compared with wild type macrophages. NTPDase1-null macrophages exposed to millimolar concentrations of ATP are more susceptible to cell death, release more interleukin-1beta and interleukin-18 after TLR2 or TLR4 priming, and incorporate the fluorescent dye Yo-Pro-1 more efficiently (suggestive of increased pore formation) than wild type cells Mus musculus
physiological function NTPDase1 is the dominant ectonucleotidase responsible for the hydrolysis of ATP and ADP at the surface of mouse primary macrophages. NTPDase1 regulates P2X7-dependent responses in peritoneal macrophages Mus musculus