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Literature summary for 3.6.1.54 extracted from

  • Babinski, K.J.; Kanjilal, S.J.; Raetz, C.R.
    Accumulation of the lipid A precursor UDP-2,3-diacylglucosamine in an Escherichia coli mutant lacking the lpxH gene (2002), J. Biol. Chem., 277, 25947-25956.
    View publication on PubMed
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
UDP-2,3-bis((3R)-3-hydroxymyristoyl)alpha-D-glucosamine + H2O Escherichia coli a step of lipid A biosynthesis. LpxH is essential in Escherichia coli 2,3-bis((3R)-3-hydroxymyristoyl)-beta-D-glucosaminyl 1-phosphate + UMP
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 ?
UDP-2,3-bis((3R)-3-hydroxymyristoyl)alpha-D-glucosamine + H2O Pseudomonas aeruginosa step of lipid A biosynthesis. Pseudomonas aeruginosa LpxH catalyzes UDP-2,3-diacylglucosamine hydrolysis in vitro and can substitute for Escherichia coli lpxH in vivo 2,3-bis((3R)-3-hydroxymyristoyl)-beta-D-glucosaminyl 1-phosphate + UMP
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 ?

Organism

Organism UniProt Comment Textmining
Escherichia coli
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-
-
Pseudomonas aeruginosa
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-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
UDP-2,3-bis((3R)-3-hydroxymyristoyl)alpha-D-glucosamine + H2O a step of lipid A biosynthesis. LpxH is essential in Escherichia coli Escherichia coli 2,3-bis((3R)-3-hydroxymyristoyl)-beta-D-glucosaminyl 1-phosphate + UMP
-
 ?
UDP-2,3-bis((3R)-3-hydroxymyristoyl)alpha-D-glucosamine + H2O step of lipid A biosynthesis. Pseudomonas aeruginosa LpxH catalyzes UDP-2,3-diacylglucosamine hydrolysis in vitro and can substitute for Escherichia coli lpxH in vivo Pseudomonas aeruginosa 2,3-bis((3R)-3-hydroxymyristoyl)-beta-D-glucosaminyl 1-phosphate + UMP
-
 ?
UDP-2,3-bis((3R)-3-hydroxymyristoyl)alpha-D-glucosamine + H2O Pseudomonas aeruginosa LpxH catalyzes UDP-2,3-diacylglucosamine hydrolysis in vitro and can substitute for Escherichia coli lpxH in vivo Pseudomonas aeruginosa 2,3-bis((3R)-3-hydroxymyristoyl)-beta-D-glucosaminyl 1-phosphate + UMP
-
 ?

Synonyms

Synonyms Comment Organism
LpxH
-
 Escherichia coli
LpxH
-
 Pseudomonas aeruginosa

General Information

General Information Comment Organism
malfunction construction of Escherichia coli mutant KB21/pKJB5 that contains a kanamycin cassette inserted into the chromosomal copy of lpxH. The plasmid pKJB5 harbors lpxH+ and features a temperature-sensitive origin of replication. KB21/pKJB5 grows on nutrient medium at 30 °C but not at 44 °C when the plasmid carrying lpxH+ is lost. It is conclude that lpxH is essential in Escherichia coli Escherichia coli