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Literature summary for 3.6.1.52 extracted from

  • Hidaka, K.; Caffrey, J.J.; Hua, L.; Zhang, T.; Falck, J.R.; Nickel, G.C.; Carrel, L.; Barnes, L.D.; Shears, S.B.
    An adjacent pair of human NUDT genes on chromosome X are preferentially expressed in testis and encode two new isoforms of diphosphoinositol polyphosphate phosphohydrolase (2002), J. Biol. Chem., 277, 32730-32738.
    View publication on PubMed
Search for more literature for 3.6.1.52

Cloned(Commentary)

Cloned (Comment) Organism
-
 Homo sapiens

Protein Variants

Protein Variants Comment Organism
P89R codes for isoenzyme hDIPP3beta Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
25000
-
 recombinant enzyme, SDS-PAGE Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
diphosphoinositol polyphosphate + H2O Homo sapiens vesicle trafficking, stress responses, DNA repair, apoptosis inositol polyphosphate + phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P07202
-
-
Homo sapiens Q96G61
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
no modification
-
 Homo sapiens

Purification (Commentary)

Purification (Comment) Organism
recombinant enzyme, by TALON metal affinity chromatography Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
testis
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
bisdiphosphoinositol tetrakisphosphate + H2O
-
 Homo sapiens diphosphoinositol pentakisphosphate + phosphate
-
 ?
bisdiphosphoinositol tetrakisphosphate + H2O specificity constant of isoenzyme hDIPP3beta is 2.7fold higher than value for isoenzyme hDIPP3alpha Homo sapiens diphosphoinositol pentakisphosphate + phosphate
-
 ?
diphosphoinositol pentakisphosphate + H2O
-
 Homo sapiens inositol hexakisphosphate + phosphate
-
 ?
diphosphoinositol pentakisphosphate + H2O isoenzyme hDIPP3beta is 2.3fold more active than isoenzyme hDIPP3alpha Homo sapiens inositol hexakisphosphate + phosphate
-
 ?
diphosphoinositol polyphosphate + H2O no activity with dGTP Homo sapiens inositol polyphosphate + phosphate
-
 ?
diphosphoinositol polyphosphate + H2O vesicle trafficking, stress responses, DNA repair, apoptosis Homo sapiens inositol polyphosphate + phosphate
-
 ?

Synonyms

Synonyms Comment Organism
diphosphoinositol polyphosphate phosphohydrolase
-
 Homo sapiens
DIPP3 isoenzyme hDIPP3alpha Homo sapiens
DIPP3 isoenzyme hDIPP3beta Homo sapiens