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Literature summary for 3.6.1.5 extracted from
- NTPDase and 5'-nucleotidase activities in synaptosomes of rabbits experimentally infected with BoHV-5 (2015), J. Neurovirol., 21, 518-524 .
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| additional information | infection with bovine herpesvirus type 5 (BoHV-5) strain SV-507/99 leads to a decrease in ectonucleotidase activity in synaptosomes from the cerebral cortex of infected rabbits, whereas an increased ectonucleotidase activity in synaptosomes from the hippocampus is observed. BoHV-5 replication results in changes in ectonucleotidase activity in the brain, which may contribute to the neurological signs commonly observed in the disease herpetic meningoencephalitis | Oryctolagus cuniculus |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| synaptosome | cortical synaptosomes and synaptosomes from hippocampus | Oryctolagus cuniculus | - |
- |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Ca2+ | required | Oryctolagus cuniculus |  |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ADP + H2O | Oryctolagus cuniculus | - |
AMP + phosphate | - |
? | |
| ATP + H2O | Oryctolagus cuniculus | - |
ADP + phosphate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Oryctolagus cuniculus | - |
New Zealand | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Oryctolagus cuniculus | - |
| cerebral cortex | - |
Oryctolagus cuniculus | - |
| hippocampus | - |
Oryctolagus cuniculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ADP + H2O | - |
Oryctolagus cuniculus | AMP + phosphate | - |
? | |
| ATP + H2O | - |
Oryctolagus cuniculus | ADP + phosphate | - |
? | |
| additional information | released inorganic phosphate is measured using the malachite green method | Oryctolagus cuniculus | ? | - |
- |
|
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| ectonucleotidase | - |
Oryctolagus cuniculus |
| NTPDase | - |
Oryctolagus cuniculus |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Oryctolagus cuniculus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 8 | - |
assay at | Oryctolagus cuniculus |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | infection with bovine herpesvirus type 5 (BoHV-5) strain SV-507/99 leads to a decrease in ectonucleotidase activity in synaptosomes from the cerebral cortex of infected rabbits, whereas an increased ectonucleotidase activity in synaptosomes from the hippocampus is observed. On day 7 p.i., NTPDase activity (ATP and ADP hydrolysis) are decreased in synaptosomes from the cerebral cortex of rabbits infected with BoHV-5 in relation to the control group. BoHV-5 replication results in changes in ectonucleotidase activity in the brain, which may contribute to the neurological signs commonly observed in the disease herpetic meningoencephalitis | Oryctolagus cuniculus |
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Release 2023.1 (January 2023)
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