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Literature summary for 3.6.1.5 extracted from

  • Maia, A.C.R.G.; Porcino, G.N.; Detoni, M.L.; Quellis, L.R.; Emidio, N.B.; Marconato, D.G.; Messias, W.F.; Soldati, L.L.; Faria-Pinto, P.; Capriles, P.V.; Coimbra, E.S.; Marques, M.J.; Vasconcelos, E.G.
    Leishmania infantum amastigote nucleoside triphosphate diphosphohydrolase 1 (NTPDase 1) Its inhibition as a new insight into mode of action of pentamidine (2019), Exp. Parasitol., 200, 1-6 .
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
additional information amphotericin B, fluconazole, ketoconazole or allopurinol do not significantly affect ATPase and/or ADPase activity of promastigotes preparation, no or poor to low (at high concentrations) inhibition Leishmania infantum
pentamidine isethionate PEN, inhibits 74% and 35% of the ATPase and ADPase activities, respectively of the purified enzyme NTPDase 1, no inhibition of NTPDase 2 Leishmania infantum

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ activates Leishmania infantum

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ADP + H2O Leishmania infantum
-
AMP + phosphate
-
?
ADP + H2O Leishmania infantum MHOM/BR/1972/BH46
-
AMP + phosphate
-
?
ATP + H2O Leishmania infantum
-
ADP + phosphate
-
?
ATP + H2O Leishmania infantum MHOM/BR/1972/BH46
-
ADP + phosphate
-
?

Organism

Organism UniProt Comment Textmining
Leishmania infantum
-
-
-
Leishmania infantum MHOM/BR/1972/BH46
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
amastigote
-
Leishmania infantum
-
additional information propagated in macrophages Leishmania infantum
-
promastigote
-
Leishmania infantum
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ADP + H2O
-
Leishmania infantum AMP + phosphate
-
?
ADP + H2O
-
Leishmania infantum MHOM/BR/1972/BH46 AMP + phosphate
-
?
ATP + H2O
-
Leishmania infantum ADP + phosphate
-
?
ATP + H2O
-
Leishmania infantum MHOM/BR/1972/BH46 ADP + phosphate
-
?

Synonyms

Synonyms Comment Organism
NTPDase 1
-
Leishmania infantum
nucleoside triphosphate diphosphohydrolase 1
-
Leishmania infantum

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Leishmania infantum

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
assay at Leishmania infantum