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Literature summary for 3.6.1.5 extracted from

  • Ho, C.L.; Yang, C.Y.; Lin, W.J.; Lin, C.H.
    Ecto-nucleoside triphosphate diphosphohydrolase 2 modulates local ATP-induced calcium signaling in human HaCaT keratinocytes (2013), PLoS ONE, 8, e57666.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.6.1.5

Inhibitors

Inhibitors Comment Organism Structure
ARL 67156 knocking down NTPDase2 expression using siRNA or inhibiting NTPDases activity with ARL 67156 simultaneously reduces ATP hydrolysis and ADP formation Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9Y5L3
-
-

Source Tissue

Source Tissue Comment Organism Textmining
keratinocyte HaCaT keratinocyte Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O
-
 Homo sapiens ADP + phosphate in the presence of NTPDase2, extracellular ATP is hydrolyzed and converted into ADP. Knocking down NTPDase2 expression using siRNA or inhibiting NTPDases activity with ARL 67156 simultaneously reduces ATP hydrolysis and ADP formation. The amount of generated ADP is proportional to the amount of ATP hydrolyzed in all treatments ?

Synonyms

Synonyms Comment Organism
ENTPD2
-
 Homo sapiens
NTPDase2
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function pharmacological inhibition by ARL 67156 or gene silencing of the endogenous ecto-nucleoside triphosphate diphosphohydrolase isoform 2 results in a 25% reduction in both ATP hydrolysis and ADP formation. NTPDase2 hydrolyzes ATP and generates sustainable ADP levels. Knocking down NTPDase2 potentiates the nanomolar ATP-induced intracellular calcium increase Homo sapiens