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Literature summary for 3.6.1.5 extracted from

  • Syed, S.K.; Kauffman, A.L.; Beavers, L.S.; Alston, J.T.; Farb, T.B.; Ficorilli, J.; Marcelo, M.C.; Brenner, M.B.; Bokvist, K.; Barrett, D.G.; Efanov, A.M.
    Ectonucleotidase NTPDase3 is abundant in pancreatic beta-cells and regulates glucose-induced insulin secretion (2013), Am. J. Physiol. Endocrinol. Metab., 305, E1319-E1326.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
ARL 67156 selective inhibitor Homo sapiens
ARL 67156 selective inhibitor Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + 2 H2O Mus musculus
-
AMP + 2 phosphate
-
?
ATP + 2 H2O Homo sapiens
-
AMP + 2 phosphate
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens O75355
-
-
Mus musculus Q8BFW6
-
-

Source Tissue

Source Tissue Comment Organism Textmining
adipose tissue
-
Homo sapiens
-
brain
-
Homo sapiens
-
esophagus
-
Homo sapiens
-
MIN-6 cell
-
Mus musculus
-
nasal mucosa
-
Homo sapiens
-
pancreas
-
Homo sapiens
-
pancreatic islet highest expression Mus musculus
-
pancreatic islet highest expression Homo sapiens
-
parathyroid
-
Homo sapiens
-
pituitary gland
-
Homo sapiens
-
salivary gland
-
Homo sapiens
-
thyroid
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 2 H2O
-
Mus musculus AMP + 2 phosphate
-
?
ATP + 2 H2O
-
Homo sapiens AMP + 2 phosphate
-
?

Synonyms

Synonyms Comment Organism
ENTPD3
-
Mus musculus
ENTPD3
-
Homo sapiens
NTPDase3
-
Mus musculus
NTPDase3
-
Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.033
-
at pH 7.4 and 37°C Mus musculus ARL 67156

General Information

General Information Comment Organism
malfunction downregulation of NTPDase3 expression in MIN-6 cells inhibits extracellular ATP hydrolysis and insulin secretion Mus musculus
physiological function the enzyme modulates insulin secretion by controlling activation of purinergic receptors Mus musculus
physiological function the enzyme modulates insulin secretion by controlling activation of purinergic receptors Homo sapiens