Inhibitors | Comment | Organism | Structure |
---|---|---|---|
ARL 67156 | selective inhibitor | Homo sapiens | |
ARL 67156 | selective inhibitor | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + 2 H2O | Mus musculus | - |
AMP + 2 phosphate | - |
? | |
ATP + 2 H2O | Homo sapiens | - |
AMP + 2 phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | O75355 | - |
- |
Mus musculus | Q8BFW6 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
adipose tissue | - |
Homo sapiens | - |
brain | - |
Homo sapiens | - |
esophagus | - |
Homo sapiens | - |
MIN-6 cell | - |
Mus musculus | - |
nasal mucosa | - |
Homo sapiens | - |
pancreas | - |
Homo sapiens | - |
pancreatic islet | highest expression | Mus musculus | - |
pancreatic islet | highest expression | Homo sapiens | - |
parathyroid | - |
Homo sapiens | - |
pituitary gland | - |
Homo sapiens | - |
salivary gland | - |
Homo sapiens | - |
thyroid | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + 2 H2O | - |
Mus musculus | AMP + 2 phosphate | - |
? | |
ATP + 2 H2O | - |
Homo sapiens | AMP + 2 phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
ENTPD3 | - |
Mus musculus |
ENTPD3 | - |
Homo sapiens |
NTPDase3 | - |
Mus musculus |
NTPDase3 | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.033 | - |
at pH 7.4 and 37°C | Mus musculus | ARL 67156 |
General Information | Comment | Organism |
---|---|---|
malfunction | downregulation of NTPDase3 expression in MIN-6 cells inhibits extracellular ATP hydrolysis and insulin secretion | Mus musculus |
physiological function | the enzyme modulates insulin secretion by controlling activation of purinergic receptors | Mus musculus |
physiological function | the enzyme modulates insulin secretion by controlling activation of purinergic receptors | Homo sapiens |