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Literature summary for 3.6.1.5 extracted from

  • Andrade, C.; Wink, M.; Margis, R.; Borojevic, R.; Battastini, A.; Guma, F.
    Changes in E-NTPDase 3 expression and extracellular nucleotide hydrolysis during the myofibroblast/lipocyte differentiation (2010), Mol. Cell. Biochem., 339, 79-87.
    View publication on PubMed
Search for more literature for 3.6.1.5

Cloned(Commentary)

Cloned (Comment) Organism
genes Entpd1, 2, 3, 5, 6, and Entpd8 Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular
-
 Mus musculus
-
-
membrane
-
 Mus musculus 16020
-

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ required Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ADP + H2O Mus musculus
-
 AMP + phosphate
-
 ?
ATP + 2 H2O Mus musculus best substrate in hepatic stellate cells AMP + 2 phosphate
-
 ?
CDP + H2O Mus musculus
-
 CMP + phosphate
-
 ?
CTP + 2 H2O Mus musculus
-
 CMP + 2 phosphate
-
 ?
GTP + 2 H2O Mus musculus
-
 GMP + 2 phosphate
-
 ?
additional information Mus musculus substrate specificity in myofibroblasts and quiescent-like hepatic stellate cells, overview ?
-
 ?
UDP + H2O Mus musculus best substrate in myofibroblasts UMP + phosphate
-
 ?
UTP + 2 H2O Mus musculus
-
 UMP + 2 phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
 genes Entpd1, 2, 3, 5, 6, and Entpd8
-

Source Tissue

Source Tissue Comment Organism Textmining
GRX cell hepatic stellate cell line. Both phenotypes of GRX cell line express NTPDase 3 and 5, but only activated cells express NTPDase 6, quantitative real-time PCR expression analysis of Entpd genes, overview Mus musculus
-
hepatic stellate cell
-
 Mus musculus
-
liver
-
 Mus musculus
-
additional information NTPs may be hydrolyzed mainly by NTPDase 3 in GRX cells and the increase in the NTPs hydrolysis observed in lipocytes is probably related to the up-regulation of Entpd3 mRNA expression Mus musculus
-
myofibroblast
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ADP + H2O
-
 Mus musculus AMP + phosphate
-
 ?
ATP + 2 H2O
-
 Mus musculus AMP + 2 phosphate
-
 ?
ATP + 2 H2O best substrate in hepatic stellate cells Mus musculus AMP + 2 phosphate
-
 ?
CDP + H2O
-
 Mus musculus CMP + phosphate
-
 ?
CTP + 2 H2O
-
 Mus musculus CMP + 2 phosphate
-
 ?
GTP + 2 H2O
-
 Mus musculus GMP + 2 phosphate
-
 ?
additional information substrate specificity in myofibroblasts and quiescent-like hepatic stellate cells, overview Mus musculus ?
-
 ?
UDP + H2O
-
 Mus musculus UMP + phosphate
-
 ?
UDP + H2O best substrate in myofibroblasts Mus musculus UMP + phosphate
-
 ?
UTP + 2 H2O
-
 Mus musculus UMP + 2 phosphate
-
 ?

Synonyms

Synonyms Comment Organism
E-NTPDase 3
-
 Mus musculus
ecto-nucleoside triphosphate diphosphohydrolase
-
 Mus musculus
NTPDase 3
-
 Mus musculus
NTPDase 5
-
 Mus musculus
NTPDase 6
-
 Mus musculus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Mus musculus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
 assay at Mus musculus

General Information

General Information Comment Organism
evolution the enzyme is a member of the E-NTPDase family Mus musculus
physiological function ecto-nucleoside triphosphate diphosphohydrolases, E-NTPDases, regulate the concentration of extracellular nucleotides, signaling molecules that play a role in the pathogenesis of hepatic fibrosis. Up-regulation of Entpd3 mRNA expression modulates the extracellular concentration of nucleotides/nucleosides and affect P2-receptor signaling differently in quiescent-like cells and may play a role in the regulation of hepatic stellate cell functions Mus musculus