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Literature summary for 3.6.1.5 extracted from

  • Leal, D.B.; Streher, C.A.; Neu, T.N.; Bittencourt, F.P.; Leal, C.A.; da Silva, J.E.; Morsch, V.M.; Schetinger, M.R.
    Characterization of NTPDase (NTPDase1; ecto-apyrase; ecto-diphosphohydrolase; CD39; EC 3.6.1.5) activity in human lymphocytes (2005), Biochim. Biophys. Acta, 1721, 9-15.
    View publication on PubMed
Search for more literature for 3.6.1.5

Inhibitors

Inhibitors Comment Organism Structure
additional information not inhibitory: P1,P5-di(adenosine-5’)pentaphosphate, ouabain, levamisole, oligomycin, N-ethylmaleimide, sodium azide Homo sapiens
orthovanadate hydrolysis of ADP Homo sapiens
Sodium azide hydrolysis of both ATP and ADP Homo sapiens
Sodium fluoride 20 mM, 50% residual ATPase activity, 56% residual ADPase activity Homo sapiens
suramin 0.3 mM, 44% residual ATPase activity, 63% residual ADPase activity Homo sapiens
Trifluoperazine 0.2 mM, 31% residual ATPase activity, 61% residual ADPase activity Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0776
-
 ATP pH 8.0, 37°C Homo sapiens
0.107
-
 ADP pH 8.0, 37°C Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
lymphocyte
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ADP + H2O 97% of the activity with ATP Homo sapiens AMP + phosphate
-
 ?
ATP + 2 H2O
-
 Homo sapiens AMP + 2 phosphate
-
 ?
GDP + H2O 35% of the activity with ATP Homo sapiens GMP + phosphate
-
 ?
GTP + 2 H2O 37% of the activity with ATP Homo sapiens GMP + 2 phosphate
-
 ?
additional information only one enzymatic site is responsible for hydrolysis of both ATP and ADP Homo sapiens ?
-
 ?
UDP + H2O 18% of the activity with ATP Homo sapiens UMP + phosphate
-
 ?
UTP + 2 H2O 40% of the activity with ATP Homo sapiens UMP + 2 phosphate
-
 ?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
-
 Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8
-
-
 Homo sapiens