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Literature summary for 3.6.1.5 extracted from

  • Cote, Y.P.; Filep, J.G.; Battistini, B.; Gauvreau, J.; Sirois, P.; Beaudoin, A.R.
    Characterization of ATP-diphosphohydrolase activities in the intima and media of bovine aorta: evidence for a regulatory role in platelet activation in vitro (1992), Biochim. Biophys. Acta, 1139, 133-142.
    View publication on PubMed
Search for more literature for 3.6.1.5

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane ectonucleotidase/ectoenzyme Bos taurus 16020
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ADP + H2O Bos taurus
-
 AMP + phosphate
-
 ?
ATP + 2 H2O Bos taurus inhibition of platelet aggregation AMP + 2 phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
aorta intima and media layers Bos taurus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.07
-
 ATP, media, fraction Bos taurus
0.08
-
 ATP, media, fraction Bos taurus
0.08
-
 ADP, intima, fraction Bos taurus
0.1
-
 ATP, intima, fraction Bos taurus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ADP + H2O
-
 Bos taurus AMP + phosphate
-
 ?
ATP + 2 H2O
-
 Bos taurus AMP + 2 phosphate
-
 ?
ATP + 2 H2O inhibition of platelet aggregation Bos taurus AMP + 2 phosphate
-
 ?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Bos taurus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
-
 Bos taurus

pH Range

pH Minimum pH Maximum Comment Organism
6 8.5 about 40% activity at pH 6, 100% activity at pH 7.5, about 55% activity at pH 8.5 Bos taurus