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Literature summary for 3.6.1.5 extracted from

  • Lemmens, R.; Kupers, L.; Sevigny, J.; Beaudoin, A.R.; Grondin, G.; Kittel, A.; Waelkens, E.; Vanduffel, L.
    Purification, characterization, and localisation of an ATP diphosphohydrolase in porcine kidney (2000), Am. J. Physiol., 278, 978-988.
No PubMed abstract available
Search for more literature for 3.6.1.5

Inhibitors

Inhibitors Comment Organism Structure
EGTA
-
 Sus scrofa
NaN3
-
 Sus scrofa

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane ectonucleotidase/ectoenzyme Sus scrofa 16020
-

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ either Mg2+ or Ca2+ required for activity Sus scrofa
Ca2+ Ca2+ preferred to Mg2+ Sus scrofa
Mg2+ either Mg2+ or Ca2+ required for activity Sus scrofa

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
78000
-
 highly glycosylated, nominal weight of 57 kDa Sus scrofa

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ADP + H2O Sus scrofa
-
 AMP + phosphate
-
 ?
ATP + 2 H2O Sus scrofa
-
 AMP + 2 phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Sus scrofa
-
 pig
-

Posttranslational Modification

Posttranslational Modification Comment Organism
glycoprotein highly glycosylated, nominal weight of 57 kDa Sus scrofa
glycoprotein N-linked oligosaccarides Sus scrofa

Purification (Commentary)

Purification (Comment) Organism
-
 Sus scrofa

Source Tissue

Source Tissue Comment Organism Textmining
kidney cortex, detected by immunoblotting in blood vessel walls of glomerular and peritubular capillaries Sus scrofa
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.4
-
 ATP Sus scrofa

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ADP + H2O
-
 Sus scrofa AMP + phosphate
-
 ?
ATP + 2 H2O
-
 Sus scrofa AMP + 2 phosphate
-
 ?
CDP + H2O
-
 Sus scrofa CMP + phosphate
-
 ?
CTP + 2 H2O
-
 Sus scrofa CMP + 2 phosphate
-
 ?
GDP + H2O
-
 Sus scrofa GMP + phosphate
-
 ?
GTP + 2 H2O
-
 Sus scrofa GMP + 2 phosphate
-
 ?
IDP + H2O
-
 Sus scrofa IMP + phosphate
-
 ?
ITP + 2 H2O
-
 Sus scrofa IMP + 2 phosphate
-
 ?
additional information neglible hydrolysis of AMP Sus scrofa ?
-
 ?
TTP + 2 H2O
-
 Sus scrofa TMP + 2 phosphate
-
 ?
UDP + H2O
-
 Sus scrofa UMP + phosphate
-
 ?
UTP + 2 H2O
-
 Sus scrofa UMP + 2 phosphate
-
 ?