Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.6.1.5 extracted from

  • Biederbick, A.; Kosan, C.; Kunz, J.; Elsaesser, H.P.
    First apyrase splice variants have different enzymatic properties (2000), J. Biol. Chem., 275, 19018-19024.
    View publication on PubMed
Search for more literature for 3.6.1.5

Cloned(Commentary)

Cloned (Comment) Organism
gene LALP70 cloned into the mammalian expression vector pCl-Neo, expression on the surface of COS-7 cells Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
additional information not being altered by P-type, F-type or V-type NTPase inhibitors Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
lysosomal membrane
-
 Homo sapiens 5765
-
membrane
-
 Homo sapiens 16020
-

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ either Mg2+ or Ca2+ required for activity Homo sapiens
Ca2+ hLALP70v either Md2+ or Ca2+ dependent Homo sapiens
Ca2+ hLALP70 prefers Ca2+ to Mg2+ Homo sapiens
Mg2+ either Mg2+ or Ca2+ required for activity Homo sapiens
Mg2+ hLALP70v either Mg2+ or Ca2+ required for activity Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
71000
-
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ADP + H2O Homo sapiens
-
 AMP + phosphate
-
 ?
ATP + 2 H2O Homo sapiens
-
 AMP + 2 phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 hLALP70 and the splice variant hLALP70v
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ADP + H2O
-
 Homo sapiens AMP + phosphate
-
 ?
ATP + 2 H2O
-
 Homo sapiens AMP + 2 phosphate
-
 ?
CDP + H2O high enzyme activity by hLALP70v Homo sapiens CMP + phosphate
-
 ?
CTP + 2 H2O highest enzyme activity by hLALP70v Homo sapiens CMP + 2 phosphate
-
 ?
GTP + 2 H2O hLALP70v Homo sapiens GMP + 2 phosphate
-
 ?
additional information neglible hydrolysis of AMP Homo sapiens ?
-
 ?
TTP + 2 H2O high enzyme activity by hLALP70 Homo sapiens TMP + 2 phosphate
-
 ?
UDP + H2O hLALP70v Homo sapiens UMP + phosphate
-
 ?
UTP + 2 H2O highest enzyme activity by hLALP70 Homo sapiens UMP + 2 phosphate
-
 ?