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Literature summary for 3.6.1.5 extracted from

  • Knowles, A.F.; Isler, R.E.; Reece, J.F.
    The common occurrence of ATP diphosphohydrolase in mammalian plasma membranes (1983), Biochim. Biophys. Acta, 731, 88-96.
    View publication on PubMed
Search for more literature for 3.6.1.5

General Stability

General Stability Organism
unstable to detergent Triton X-100 Homo sapiens
unstable to detergent Triton X-100 Mus sp.

Inhibitors

Inhibitors Comment Organism Structure
adenosine 5'-[beta,gamma-imido]triphosphate
-
 Mus sp.
fluoride
-
 Canis lupus
fluoride
-
 Homo sapiens
fluoride
-
 Mus sp.
Mn2+ at higher concentrations Mus sp.
N3-
-
 Canis lupus
N3-
-
 Homo sapiens
N3-
-
 Mus sp.

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
 Homo sapiens 16020
-
membrane
-
 Canis lupus 16020
-
membrane
-
 Mus sp. 16020
-

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ either Mg2+ or Ca2+ required for activity Homo sapiens
Ca2+ either Mg2+ or Ca2+ required for activity Canis lupus
Ca2+ either Mg2+ or Ca2+ required for activity Mus sp.
Mg2+ either Mg2+ or Ca2+ required for activity Homo sapiens
Mg2+ either Mg2+ or Ca2+ required for activity Canis lupus
Mg2+ either Mg2+ or Ca2+ required for activity Mus sp.
Mn2+
-
 Homo sapiens
Mn2+
-
 Mus sp.

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ADP + H2O Homo sapiens
-
 AMP + phosphate
-
 ?
ADP + H2O Canis lupus
-
 AMP + phosphate
-
 ?
ADP + H2O Mus sp.
-
 AMP + phosphate
-
 ?
ATP + 2 H2O Homo sapiens
-
 AMP + 2 phosphate
-
 ?
ATP + 2 H2O Canis lupus
-
 AMP + 2 phosphate
-
 ?
ATP + 2 H2O Mus sp.
-
 AMP + 2 phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Canis lupus
-
 dog
-
Homo sapiens
-
-
-
Mus sp.
-
 mouse
-

Source Tissue

Source Tissue Comment Organism Textmining
astrocytoma cell
-
 Homo sapiens
-
kidney
-
 Homo sapiens
-
kidney
-
 Canis lupus
-
liver
-
 Mus sp.
-
sarcoma cell
-
 Mus sp.
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ADP + H2O
-
 Homo sapiens AMP + phosphate
-
 ?
ADP + H2O
-
 Canis lupus AMP + phosphate
-
 ?
ADP + H2O
-
 Mus sp. AMP + phosphate
-
 ?
ATP + 2 H2O
-
 Homo sapiens AMP + 2 phosphate
-
 ?
ATP + 2 H2O
-
 Canis lupus AMP + 2 phosphate
-
 ?
ATP + 2 H2O
-
 Mus sp. AMP + 2 phosphate
-
 ?
CTP + 2 H2O
-
 Homo sapiens CMP + 2 phosphate
-
 ?
CTP + 2 H2O
-
 Mus sp. CMP + 2 phosphate
-
 ?
GTP + 2 H2O
-
 Homo sapiens GMP + 2 phosphate
-
 ?
GTP + 2 H2O
-
 Mus sp. GMP + 2 phosphate
-
 ?
ITP + 2 H2O
-
 Mus sp. IMP + 2 phosphate
-
 ?
additional information neglible hydrolysis of AMP Homo sapiens ?
-
 ?
additional information neglible hydrolysis of AMP Canis lupus ?
-
 ?
additional information neglible hydrolysis of AMP Mus sp. ?
-
 ?
UDP + H2O
-
 Homo sapiens UMP + phosphate
-
 ?
UDP + H2O
-
 Mus sp. UMP + phosphate
-
 ?
UTP + 2 H2O
-
 Homo sapiens UMP + 2 phosphate
-
 ?
UTP + 2 H2O
-
 Mus sp. UMP + 2 phosphate
-
 ?

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
75
-
 10 min, 60% activity remain Mus sp.

pH Range

pH Minimum pH Maximum Comment Organism
7 8
-
 Mus sp.