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Literature summary for 3.6.1.42 extracted from

  • Sanchez, R.; Franco, A.; Gacto, M.; Notario, V.; Cansado, J.
    Characterization of gdp1+ as encoding a GDPase in the fission yeast Schizosaccharomyces pombe (2003), FEMS Microbiol. Lett., 228, 33-38.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
overexpression in Schizosaccharomyces pombe, functional complementation of a Saccharomyces cerevisiae enzyme mutant defective in chitinase O-mannosylation Schizosaccharomyces pombe

Protein Variants

Protein Variants Comment Organism
additional information construction of s disruption mutant showing defects in N-glycosylation of other proteins Schizosaccharomyces pombe

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
Schizosaccharomyces pombe 16020
-
microsome
-
Schizosaccharomyces pombe
-
-

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ highly dependent on Schizosaccharomyces pombe
Mg2+ slight activation Schizosaccharomyces pombe
Mn2+ highly dependent on, best at 20 mM Schizosaccharomyces pombe

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
GDP + H2O Schizosaccharomyces pombe the enzyme has a main role in protein glycosylation, enzyme deficiency leads to N-glycosylation defects of invertase GMP + phosphate
-
?

Organism

Organism UniProt Comment Textmining
Schizosaccharomyces pombe
-
several strains, gene gdp1+
-

Reaction

Reaction Comment Organism Reaction ID
GDP + H2O = GMP + phosphate also acts on UDP Schizosaccharomyces pombe

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ADP + H2O low activity Schizosaccharomyces pombe AMP + phosphate
-
?
ATP + H2O low activity Schizosaccharomyces pombe ADP + phosphate
-
?
GDP + H2O
-
Schizosaccharomyces pombe GMP + phosphate
-
?
GDP + H2O the enzyme has a main role in protein glycosylation, enzyme deficiency leads to N-glycosylation defects of invertase Schizosaccharomyces pombe GMP + phosphate
-
?
additional information bifunctional enzyme showing GDPase and uridine diphosphatase activities in vitro Schizosaccharomyces pombe ?
-
?
UDP + H2O
-
Schizosaccharomyces pombe UMP + phosphate
-
?

Synonyms

Synonyms Comment Organism
Gdp1p
-
Schizosaccharomyces pombe
GDPase
-
Schizosaccharomyces pombe
guanosine diphosphatase
-
Schizosaccharomyces pombe