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Literature summary for 3.6.1.42 extracted from
- Both normal and transforming PCPH proteins have guanosine diphosphatase activity but only the oncoprotein cooperates with ras in activating extracellular signal-regulated kinase ERK1 (2000), Cancer Res., 60, 1720-1728.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| normal and transforming PCPH proteins: PCPH, PCPH proto-oncogene and mt-PCPH, PCPH oncogene having guanosine diphosphatase activity | Mus musculus |
| normal and transforming PCPH proteins: PCPH, PCPH proto-oncogene and mt-PCPH, PCPH oncogene having guanosine diphosphatase activity | Homo sapiens |
| normal and transforming PCPH proteins: PCPH, PCPH proto-oncogene and mt-PCPH, PCPH oncogene having guanosine diphosphatase activity, expression in Escherichia coli BL21, DE3 | Mesocricetus auratus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
normal and transforming PCPH proteins: PCPH, PCPH proto-oncogene and mt-PCPH, PCPH oncogene having guanosine diphosphatase activity | - |
| Mesocricetus auratus | - |
Syrian hamster, normal and transforming PCPH proteins: PCPH, PCPH proto-oncogene and mt-PCPH, PCPH oncogene having guanosine diphosphatase activity | - |
| Mus musculus | - |
normal and transforming PCPH proteins: PCPH, PCPH proto-oncogene and mt-PCPH, PCPH oncogene having guanosine diphosphatase activity | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| normal and transforming PCPH proteins: PCPH, PCPH proto-oncogene and mt-PCPH, PCPH oncogene having guanosine diphosphatase activity, recombinant proteins from Escherichia coli BL21, DE3. Purified bacterial recombinant PCPH and mt-PCPH proteins have GDPase activity | Mesocricetus auratus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| embryo | - |
Mesocricetus auratus | - |
| fibroblast | - |
Mesocricetus auratus | - |
| kidney | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| GDP + H2O | PCPH and mt-PCPH proteins have intrinsic GDPase activity, are GDPases | Mus musculus | 5'-GMP + phosphate | - |
? |  |
| GDP + H2O | PCPH and mt-PCPH proteins have intrinsic GDPase activity, are GDPases | Homo sapiens | 5'-GMP + phosphate | - |
? | |
| GDP + H2O | PCPH and mt-PCPH proteins have intrinsic GDPase activity, are GDPases | Mesocricetus auratus | 5'-GMP + phosphate | - |
? | |
| IDP + H2O | - |
Mus musculus | IMP + phosphate | - |
? | |
| IDP + H2O | - |
Homo sapiens | IMP + phosphate | - |
? | |
| IDP + H2O | - |
Mesocricetus auratus | IMP + phosphate | - |
? | |
| UDP + H2O | - |
Mus musculus | UMP + phosphate | - |
? | |
| UDP + H2O | - |
Homo sapiens | UMP + phosphate | - |
? | |
| UDP + H2O | - |
Mesocricetus auratus | UMP + phosphate | - |
? | |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Mus musculus |
| 37 | - |
assay at | Homo sapiens |
| 37 | - |
assay at | Mesocricetus auratus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.5 | - |
assay at | Mus musculus |
| 7.5 | - |
assay at | Homo sapiens |
| 7.5 | - |
assay at | Mesocricetus auratus |
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Release 2023.1 (January 2023)
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