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Literature summary for 3.6.1.40 extracted from

  • Malde, A.; Gangaiah, D.; Chandrashekhar, K.; Pina-Mimbela, R.; Torrelles, J.B.; Rajashekara, G.
    Functional characterization of exopolyphosphatase/guanosine pentaphosphate phosphohydrolase (PPX/GPPA) of Campylobacter jejuni (2014), Virulence, 5, 521-533.
    View publication on PubMedView publication on EuropePMC

Organism

Organism UniProt Comment Textmining
Campylobacter jejuni A0A0H3PAT6
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Campylobacter jejuni A0A0H3PES2
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Campylobacter jejuni 81-176 A0A0H3PAT6
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Campylobacter jejuni 81-176 A0A0H3PES2
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-

Synonyms

Synonyms Comment Organism
CJJ81176_0377
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Campylobacter jejuni
CJJ81176_1251
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Campylobacter jejuni
PPX1
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Campylobacter jejuni

General Information

General Information Comment Organism
physiological function deletion mutants of exopolyphosphatases Ppx1, and the double knockout mutant Ppx1/Ppx2 show decreased accumulation of ppGpp, an alarmone molecule. The lack of ppx gene products results in defects in motility, biofilm formation, nutrient stress survival, invasion and intracellular survival indicating that maintaining a certain level of polyphosphate is critical for Ppx genes in Campylobacter jejuni pathophysiology. Both Ppx1 and Ppx2 mutants are resistant to human complement-mediated killing. The double mutant mutant is sensitive. The serum susceptibility does not occur in the presence of MgCl2 and EGTA. The chicken serum does not have any effect on the mutants' survival. The observed serum susceptibility is not related to surface capsule and lipooligosaccharide structures Campylobacter jejuni
physiological function double deletion mutants of exopolyphosphatases Ppx1/Ppx2 show decreased accumulation of ppGpp, an alarmone molecule. The lack of ppx gene products results in defects in motility, biofilm formation, nutrient stress survival, invasion and intracellular survival indicating that maintaining a certain level of polyphosphate is critical for Ppx genes in Campylobacter jejuni pathophysiology. Both Ppx1 and Ppx2 mutants are resistant to human complement-mediated killing. The double mutant mutant is sensitive. The serum susceptibility does not occur in the presence of MgCl2 and EGTA. The chicken serum does not have any effect on the mutants' survival. The observed serum susceptibility is not related to surface capsule and lipooligosaccharide structures Campylobacter jejuni