BRENDA - Enzyme Database show
show all sequences of 3.6.1.31

The product of the his4 gene cluster in Saccharomyces cerevisiae. A trifunctional polypeptide

Keesey, J.K.; Bigelis, R.; Fink, G.R.; J. Biol. Chem. 254, 7427-7433 (1979)

Data extracted from this reference:

Molecular Weight [Da]
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
95000
-
SDS-PAGE
Saccharomyces cerevisiae
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
N-1-(5'-phosphoribosyl)-ATP + H2O
Saccharomyces cerevisiae
enzyme of histidine biosynthesis pathway
N-1-(5'-phosphoribosyl)-AMP + diphosphate
-
Saccharomyces cerevisiae
?
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Saccharomyces cerevisiae
-
-
-
Purification (Commentary)
Commentary
Organism
-
Saccharomyces cerevisiae
Specific Activity [micromol/min/mg]
Specific Activity Minimum [Ámol/min/mg]
Specific Activity Maximum [Ámol/min/mg]
Commentary
Organism
332
-
purified enzyme
Saccharomyces cerevisiae
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
N-1-(5'-phosphoribosyl)-ATP + H2O
-
210041
Saccharomyces cerevisiae
N-1-(5'-phosphoribosyl)-AMP + diphosphate
-
210041
Saccharomyces cerevisiae
-
N-1-(5'-phosphoribosyl)-ATP + H2O
enzyme of histidine biosynthesis pathway
210041
Saccharomyces cerevisiae
N-1-(5'-phosphoribosyl)-AMP + diphosphate
-
210041
Saccharomyces cerevisiae
?
Subunits
Subunits
Commentary
Organism
dimer
2 * 95000, gel filtration, SDS-PAGE
Saccharomyces cerevisiae
Molecular Weight [Da] (protein specific)
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
95000
-
SDS-PAGE
Saccharomyces cerevisiae
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
N-1-(5'-phosphoribosyl)-ATP + H2O
Saccharomyces cerevisiae
enzyme of histidine biosynthesis pathway
N-1-(5'-phosphoribosyl)-AMP + diphosphate
-
Saccharomyces cerevisiae
?
Purification (Commentary) (protein specific)
Commentary
Organism
-
Saccharomyces cerevisiae
Specific Activity [micromol/min/mg] (protein specific)
Specific Activity Minimum [Ámol/min/mg]
Specific Activity Maximum [Ámol/min/mg]
Commentary
Organism
332
-
purified enzyme
Saccharomyces cerevisiae
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
N-1-(5'-phosphoribosyl)-ATP + H2O
-
210041
Saccharomyces cerevisiae
N-1-(5'-phosphoribosyl)-AMP + diphosphate
-
210041
Saccharomyces cerevisiae
-
N-1-(5'-phosphoribosyl)-ATP + H2O
enzyme of histidine biosynthesis pathway
210041
Saccharomyces cerevisiae
N-1-(5'-phosphoribosyl)-AMP + diphosphate
-
210041
Saccharomyces cerevisiae
?
Subunits (protein specific)
Subunits
Commentary
Organism
dimer
2 * 95000, gel filtration, SDS-PAGE
Saccharomyces cerevisiae
Other publictions for EC 3.6.1.31
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [░C]
Temperature Range [░C]
Temperature Stability [░C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [░C] (protein specific)
Temperature Range [░C] (protein specific)
Temperature Stability [░C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
695322
Javid-Majd
The 1.25 A resolution structur ...
Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv
Acta Crystallogr. Sect. D
64
627-635
2008
-
1
-
1
-
-
-
-
-
1
-
4
-
7
-
-
-
-
-
-
-
-
6
2
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
1
-
4
-
-
-
-
-
-
-
-
6
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
210042
Fujimori
Isolation and characterization ...
Arabidopsis sp.
Plant Physiol.
118
275-283
1998
-
-
1
-
-
-
-
-
-
-
1
1
-
5
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
210041
Keesey
The product of the his4 gene c ...
Saccharomyces cerevisiae
J. Biol. Chem.
254
7427-7433
1979
-
-
-
-
-
-
-
-
-
-
1
1
-
1
-
-
1
-
-
-
1
-
2
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
1
-
-
1
-
2
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
210040
Smith
Phosphoribosyladenosine monoph ...
Salmonella enterica subsp. enterica serovar Typhimurium
J. Biol. Chem.
240
3056-3063
1965
-
-
-
-
-
-
1
1
-
1
1
1
-
1
-
-
1
-
-
-
1
-
2
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
1
1
1
-
-
-
1
-
-
1
-
2
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-