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Literature summary for 3.6.1.29 extracted from

  • Barnes, L.D.; Garrison, P.N.; Siprashvili, Z.; Guranowski, A.; Robinson, A.K.; Ingram, S.W.; Croce, C.M.; Ohta, M.; Huebner, K.
    Fhit, a putative tumor supressor in humans, is a dinucleoside 5',5'''-P1,P3-triphosphate hydrolase (1996), Biochemistry, 35, 11529-11535.
    View publication on PubMed
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Cloned(Commentary)

Cloned (Comment) Organism
expression in COS1 cells Homo sapiens
expression in Escherichia coli Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
Zn2+
-
 Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0013
-
 P1-P3-bis(5'-adenosyl) triphosphate
-
 Homo sapiens
0.0046
-
 Ap4A
-
 Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Co2+
-
 Homo sapiens
Mg2+
-
 Homo sapiens
Mn2+
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
P1-P3-bis(5'-adenosyl) triphosphate + H2O Homo sapiens
-
 ADP + AMP
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
breast
-
 Homo sapiens
-
colon
-
 Homo sapiens
-
esophagus
-
 Homo sapiens
-
kidney
-
 Homo sapiens
-
lung
-
 Homo sapiens
-
stomach
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Ap4A + H2O
-
 Homo sapiens ?
-
 ?
Ap6A + H2O
-
 Homo sapiens ?
-
 ?
diadenosine 5',5''-P1,P4-tetraphosphate + H2O
-
 Homo sapiens AMP + ATP
-
 ?
diadenosine 5',5''-P1,P5-pentaphosphate + H2O
-
 Homo sapiens AMP + adenosine 5'-tetraphosphate
-
 ?
P1-P3-bis(5'-adenosyl) triphosphate + H2O
-
 Homo sapiens ADP + AMP
-
 ?