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Literature summary for 3.6.1.28 extracted from
- Properties of chicken liver membrane-associated thiamine triphosphatase (2015), Ukr. Biochem. J., 87, 37-46 .
General Stability
| General Stability | Organism |
|---|---|
| the precipitate treatment with 1% (v/v) sodium deoxycholate causes about 53% solubilization of the enzyme activity | Gallus gallus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Br- | inhibitory at 150 mM | Gallus gallus |  |
| Cl- | inhibitory at 150 mM | Gallus gallus | |
| I- | inhibitory at 150 mM | Gallus gallus | |
| NO3- | inhibitory at 150 mM | Gallus gallus | |
| SCN- | inhibitory at 150 mM | Gallus gallus | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 1.7 | 2.2 | thiamine triphosphate | apparent value, in the presence of 5 mM Mg2+, pH and temperature not specified in the publication | Gallus gallus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| membrane | - |
Gallus gallus | 16020 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Ca2+ | the addition of Ca2+ at 5 mM concentration enhances the rate of thiamine triphosphate hydrolysis by a factor of 17-20 | Gallus gallus | |
| Mg2+ | the addition of Mg2+ at 5 mM concentration enhances the rate of thiamine triphosphate hydrolysis by a factor of 17-20 | Gallus gallus | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| thiamine triphosphate + H2O | Gallus gallus | - |
thiamine diphosphate + phosphate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Gallus gallus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| Toyopeal HW-55 column chromatography | Gallus gallus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Gallus gallus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| thiamine triphosphate + H2O | - |
Gallus gallus | thiamine diphosphate + phosphate | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| thiamine triphosphatase | - |
Gallus gallus |
| ThTPase | - |
Gallus gallus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 5.5 | 6 | - |
Gallus gallus |
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Release 2023.1 (January 2023)
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