BRENDA - Enzyme Database show
show all sequences of 3.6.1.28

Thiamine triphosphate and thiamine triphosphatase activities: from bacteria to mammals

Makarchikov, A.F.; Lakaye, B.; Gulyai, I.E.; Czerniecki, J.; Coumans, B.; Wins, P.; Grisar, T.; Bettendorff, L.; Cell. Mol. Life Sci. 60, 1477-1488 (2003)

Data extracted from this reference:

KM Value [mM]
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.016
-
thiamine triphosphate
enzyme from brain
Rattus norvegicus
0.0201
-
thiamine triphosphate
enzyme from embryonic brain
Rattus norvegicus
0.0211
-
thiamin triphosphate
enzyme from liver
Bos taurus
0.0228
-
thiamine triphosphate
enzyme from kidney
Rattus norvegicus
0.0253
-
thiamine triphosphate
enzyme from embryonic liver
Rattus norvegicus
0.0278
-
thiamine triphosphate
enzyme from liver
Rattus norvegicus
0.0338
-
thiamin triphosphate
enzyme from spleen
Bos taurus
0.0359
-
thiamin triphosphate
enzyme from trapezius
Bos taurus
0.0388
-
thiamin triphosphate
enzyme from lung
Bos taurus
0.0406
-
thiamin triphosphate
enzyme from heart
Bos taurus
0.0441
-
thiamin triphosphate
enzyme from brain
Bos taurus
0.0446
-
thiamin triphosphate
enzyme from duodenum
Bos taurus
0.0451
-
thiamin triphosphate
enzyme from kidney
Bos taurus
0.0495
-
thiamine triphosphate
enzyme from kidney
Sus scrofa
0.126
-
thiamin triphosphate
-
Homo sapiens
Molecular Weight [Da]
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
additional information
-
molecular weight of enzyme from brain and pectoralis muscle is above 80000 Da
Gallus gallus
additional information
-
the molecular weight of the brain enzyme is above 80000 Da
quail
25550
-
gel filtration
Homo sapiens
26300
-
brain enzyme, gel filtration
Bos taurus
27200
-
lung enzyme, gel filtration
Bos taurus
27600
-
trapezius muscle enzyme, gel filtration
Bos taurus
28300
-
kidney enzyme, gel filtration
Bos taurus
28400
-
liver enzyme, gel filtratuon
Bos taurus
29000
-
spleen enzyme, gel filtration
Bos taurus
29100
-
heart enzyme, gel filtration
Bos taurus
29700
-
liver enzyme, gel filtratuon
Rattus norvegicus
31000
-
enzyme from embryo, gel filtration
Rattus norvegicus
31700
-
duodenum enzyme, gel filtration
Bos taurus
32000
-
muscle enzyme, gel filtration
Rattus norvegicus
32200
-
brain enzyme, gel filtration
Rattus norvegicus
33900
-
gel filtration
Sus scrofa
34000
-
kidney enzyme, gel filtration
Rattus norvegicus
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Bos taurus
-
-
-
Gallus gallus
-
-
-
Homo sapiens
-
-
-
quail
-
-
-
Rattus norvegicus
-
-
-
Sus scrofa
-
-
-
Source Tissue
Source Tissue
Commentary
Organism
Textmining
brain
309 nmol per min per mg of wet weight
Bos taurus
-
brain
-
Gallus gallus
-
brain
-
quail
-
brain
-
Rattus norvegicus
-
brain
-
Sus scrofa
-
cerebellum
-
Homo sapiens
-
duodenum
33 nmol per min per mg of wet weight
Bos taurus
-
embryo
-
Rattus norvegicus
-
heart
217 nmol per min per mg of wet weight
Bos taurus
-
heart
-
quail
-
kidney
377 nmol per min per mg of wet weight
Bos taurus
-
kidney
-
quail
-
kidney
-
Rattus norvegicus
-
kidney
-
Sus scrofa
-
liver
354 nmol per min per mg of wet weight
Bos taurus
-
liver
-
quail
-
liver
-
Rattus norvegicus
-
lung
333 nmol per min per mg of wet weight
Bos taurus
-
lymph node
220 nmol per min per mg of wet weight
Bos taurus
-
muscle
trapezius, 169 nmol per min per mg of wet weight
Bos taurus
-
muscle
pectoralis
Gallus gallus
-
muscle
pectoralis
quail
-
muscle
quadriceps
Rattus norvegicus
-
skeletal muscle
-
Sus scrofa
-
spleen
275 nmol per min per mg of wet weight
Bos taurus
-
Specific Activity [micromol/min/mg]
Specific Activity Minimum [µmol/min/mg]
Specific Activity Maximum [µmol/min/mg]
Commentary
Organism
0.0003
-
activity in quadriceps
quail
0.0006
-
activity in brain; activity in heart
quail
0.0008
-
activity in kidney
quail
0.0024
-
activity in liver
quail
0.0114
-
activity in brain
Gallus gallus
0.0125
-
activity in skeletal muscle
Sus scrofa
0.0162
-
activity in kidney
Sus scrofa
0.033
-
duodenum
Bos taurus
0.052
-
activity in quadriceps
Rattus norvegicus
0.057
-
cerebellum
Homo sapiens
0.169
-
trapezius muscle
Bos taurus
0.189
-
activity in kidney
Rattus norvegicus
0.217
-
heart
Bos taurus
0.22
-
lymph node
Bos taurus
0.275
-
spleen
Bos taurus
0.299
-
activity in liver
Rattus norvegicus
0.309
-
brain
Bos taurus
0.333
-
lung
Bos taurus
0.354
-
liver
Bos taurus
0.377
-
kidney
Bos taurus
0.437
-
activity in brain
Rattus norvegicus
0.932
-
activity in pectoralis muscle
Gallus gallus
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
thiamin triphosphate + H2O
-
655198
Rattus norvegicus
thiamine diphosphate + phosphate
-
-
-
?
thiamine triphosphate + H2O
-
655198
Gallus gallus
thiamine diphosphate + phosphate
-
-
-
?
thiamine triphosphate + H2O
-
655198
Homo sapiens
thiamine diphosphate + phosphate
-
-
-
?
thiamine triphosphate + H2O
-
655198
Sus scrofa
thiamine diphosphate + phosphate
-
-
-
?
thiamine triphosphate + H2O
-
655198
Bos taurus
thiamine diphosphate + phosphate
-
-
-
?
thiamine triphosphate + H2O
-
655198
quail
thiamine diphosphate + phosphate
-
-
-
?
KM Value [mM] (protein specific)
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.016
-
thiamine triphosphate
enzyme from brain
Rattus norvegicus
0.0201
-
thiamine triphosphate
enzyme from embryonic brain
Rattus norvegicus
0.0211
-
thiamin triphosphate
enzyme from liver
Bos taurus
0.0228
-
thiamine triphosphate
enzyme from kidney
Rattus norvegicus
0.0253
-
thiamine triphosphate
enzyme from embryonic liver
Rattus norvegicus
0.0278
-
thiamine triphosphate
enzyme from liver
Rattus norvegicus
0.0338
-
thiamin triphosphate
enzyme from spleen
Bos taurus
0.0359
-
thiamin triphosphate
enzyme from trapezius
Bos taurus
0.0388
-
thiamin triphosphate
enzyme from lung
Bos taurus
0.0406
-
thiamin triphosphate
enzyme from heart
Bos taurus
0.0441
-
thiamin triphosphate
enzyme from brain
Bos taurus
0.0446
-
thiamin triphosphate
enzyme from duodenum
Bos taurus
0.0451
-
thiamin triphosphate
enzyme from kidney
Bos taurus
0.0495
-
thiamine triphosphate
enzyme from kidney
Sus scrofa
0.126
-
thiamin triphosphate
-
Homo sapiens
Molecular Weight [Da] (protein specific)
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
additional information
-
molecular weight of enzyme from brain and pectoralis muscle is above 80000 Da
Gallus gallus
additional information
-
the molecular weight of the brain enzyme is above 80000 Da
quail
25550
-
gel filtration
Homo sapiens
26300
-
brain enzyme, gel filtration
Bos taurus
27200
-
lung enzyme, gel filtration
Bos taurus
27600
-
trapezius muscle enzyme, gel filtration
Bos taurus
28300
-
kidney enzyme, gel filtration
Bos taurus
28400
-
liver enzyme, gel filtratuon
Bos taurus
29000
-
spleen enzyme, gel filtration
Bos taurus
29100
-
heart enzyme, gel filtration
Bos taurus
29700
-
liver enzyme, gel filtratuon
Rattus norvegicus
31000
-
enzyme from embryo, gel filtration
Rattus norvegicus
31700
-
duodenum enzyme, gel filtration
Bos taurus
32000
-
muscle enzyme, gel filtration
Rattus norvegicus
32200
-
brain enzyme, gel filtration
Rattus norvegicus
33900
-
gel filtration
Sus scrofa
34000
-
kidney enzyme, gel filtration
Rattus norvegicus
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
brain
309 nmol per min per mg of wet weight
Bos taurus
-
brain
-
Gallus gallus
-
brain
-
quail
-
brain
-
Rattus norvegicus
-
brain
-
Sus scrofa
-
cerebellum
-
Homo sapiens
-
duodenum
33 nmol per min per mg of wet weight
Bos taurus
-
embryo
-
Rattus norvegicus
-
heart
217 nmol per min per mg of wet weight
Bos taurus
-
heart
-
quail
-
kidney
377 nmol per min per mg of wet weight
Bos taurus
-
kidney
-
quail
-
kidney
-
Rattus norvegicus
-
kidney
-
Sus scrofa
-
liver
354 nmol per min per mg of wet weight
Bos taurus
-
liver
-
quail
-
liver
-
Rattus norvegicus
-
lung
333 nmol per min per mg of wet weight
Bos taurus
-
lymph node
220 nmol per min per mg of wet weight
Bos taurus
-
muscle
trapezius, 169 nmol per min per mg of wet weight
Bos taurus
-
muscle
pectoralis
Gallus gallus
-
muscle
pectoralis
quail
-
muscle
quadriceps
Rattus norvegicus
-
skeletal muscle
-
Sus scrofa
-
spleen
275 nmol per min per mg of wet weight
Bos taurus
-
Specific Activity [micromol/min/mg] (protein specific)
Specific Activity Minimum [µmol/min/mg]
Specific Activity Maximum [µmol/min/mg]
Commentary
Organism
0.0003
-
activity in quadriceps
quail
0.0006
-
activity in brain; activity in heart
quail
0.0008
-
activity in kidney
quail
0.0024
-
activity in liver
quail
0.0114
-
activity in brain
Gallus gallus
0.0125
-
activity in skeletal muscle
Sus scrofa
0.0162
-
activity in kidney
Sus scrofa
0.033
-
duodenum
Bos taurus
0.052
-
activity in quadriceps
Rattus norvegicus
0.057
-
cerebellum
Homo sapiens
0.169
-
trapezius muscle
Bos taurus
0.189
-
activity in kidney
Rattus norvegicus
0.217
-
heart
Bos taurus
0.22
-
lymph node
Bos taurus
0.275
-
spleen
Bos taurus
0.299
-
activity in liver
Rattus norvegicus
0.309
-
brain
Bos taurus
0.333
-
lung
Bos taurus
0.354
-
liver
Bos taurus
0.377
-
kidney
Bos taurus
0.437
-
activity in brain
Rattus norvegicus
0.932
-
activity in pectoralis muscle
Gallus gallus
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
thiamin triphosphate + H2O
-
655198
Rattus norvegicus
thiamine diphosphate + phosphate
-
-
-
?
thiamine triphosphate + H2O
-
655198
Gallus gallus
thiamine diphosphate + phosphate
-
-
-
?
thiamine triphosphate + H2O
-
655198
Homo sapiens
thiamine diphosphate + phosphate
-
-
-
?
thiamine triphosphate + H2O
-
655198
Sus scrofa
thiamine diphosphate + phosphate
-
-
-
?
thiamine triphosphate + H2O
-
655198
Bos taurus
thiamine diphosphate + phosphate
-
-
-
?
thiamine triphosphate + H2O
-
655198
quail
thiamine diphosphate + phosphate
-
-
-
?
Other publictions for EC 3.6.1.28
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
751047
Martinez
Structural determinants for s ...
Mus musculus
J. Biol. Chem.
290
23348-23360
2015
-
-
-
1
-
-
-
-
-
1
-
1
-
3
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
733393
Delvaux
Structural determinants of spe ...
Homo sapiens, Mus musculus
Biochim. Biophys. Acta
1830
4513-4523
2013
-
-
2
1
9
-
-
10
-
1
-
-
-
2
-
-
-
-
-
-
-
-
1
-
-
-
-
9
-
-
-
-
-
-
-
-
-
2
-
1
9
-
-
-
-
10
-
1
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
9
-
-
-
-
-
-
-
-
7
7
687693
Song
Structural basis for the catal ...
Mus musculus
J. Biol. Chem.
283
10939-10948
2008
-
-
-
-
-
-
1
1
1
1
1
1
-
2
-
-
-
1
-
-
-
-
2
1
1
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
1
1
1
1
-
-
-
-
-
-
-
-
2
1
1
-
-
-
1
-
-
-
-
-
-
-
-
-
696404
Kovacevic
The iron-regulated metastasis ...
Homo sapiens, Rattus norvegicus
Biochim. Biophys. Acta
1783
1981-1992
2008
2
-
2
-
2
-
-
-
-
-
-
2
-
2
-
-
-
-
-
3
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
2
-
2
-
-
2
-
-
-
-
-
-
-
-
2
-
-
-
-
-
3
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
667797
Szyniarowski Piot
Pig tissues express a catalyti ...
Homo sapiens, Sus scrofa
Biochim. Biophys. Acta
1725
93-102
2005
-
-
2
-
4
-
2
3
-
5
2
-
-
6
-
-
2
-
-
1
16
-
2
-
-
-
1
-
5
-
-
-
2
-
1
-
-
2
-
-
4
-
1
2
2
3
-
5
2
-
-
-
-
2
-
1
16
-
2
-
-
-
1
-
5
-
-
-
-
-
-
-
-
-
655738
Lakaye
Human recombinant thiamine tri ...
Homo sapiens
Int. J. Biochem. Cell Biol.
36
1348-1364
2004
-
-
1
-
-
-
6
2
1
2
-
-
-
3
-
-
1
-
-
-
1
-
2
-
-
-
2
2
1
1
-
-
2
-
1
-
-
1
-
-
-
-
1
7
2
2
1
2
-
-
-
-
-
1
-
-
1
-
2
-
-
-
2
2
1
1
-
-
-
-
-
-
-
-
656873
Czerniecki
Neuronal localization of the 2 ...
Rattus norvegicus
Neuroscience
125
833-840
2004
-
-
-
-
-
-
-
-
1
-
-
1
-
4
-
-
-
-
-
3
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
3
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
668963
Lakaye
Expression of 25 kDa thiamine ...
Mus musculus, Rattus norvegicus
Int. J. Biochem. Cell Biol.
36
2032-2041
2004
-
-
-
-
-
-
-
1
-
-
-
-
-
5
-
-
-
-
-
16
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
16
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
655198
Makarchikov
Thiamine triphosphate and thia ...
Bos taurus, Gallus gallus, Homo sapiens, quail, Rattus norvegicus, Sus scrofa
Cell. Mol. Life Sci.
60
1477-1488
2003
-
-
-
-
-
-
-
15
-
-
17
-
-
12
-
-
-
-
-
25
22
-
6
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
15
-
-
17
-
-
-
-
-
-
25
22
-
6
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
656042
Lakaye
Molecular characterization of ...
Bos taurus, Homo sapiens
J. Biol. Chem.
277
13771-13777
2002
-
-
1
-
-
-
4
2
1
-
6
-
-
7
-
-
2
-
-
9
2
-
4
2
-
-
-
2
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
4
-
2
1
-
6
-
-
-
-
2
-
9
2
-
4
2
-
-
-
2
-
-
-
-
-
-
-
-
-
-
210023
Makarchikov
Thiamine triphosphatase activi ...
Bos taurus
Biochem. Mol. Biol. Int.
46
115-123
1998
-
-
-
-
-
-
-
2
-
-
1
-
-
2
-
-
-
-
-
1
-
-
2
-
-
-
-
-
1
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210021
Bettendorff
Thiamine, thiamine phosphates, ...
Homo sapiens
J. Neurochem.
66
250-258
1996
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210020
Makarchikov
Purification and characterizat ...
Bos taurus
Biochim. Biophys. Acta
1117
326-332
1992
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1
2
7
1
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1
1
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210012
Matsuda
Membrane-associated thiamine t ...
Rattus norvegicus
Int. J. Biochem.
23
1111-1114
1991
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9
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210022
Bettendorff
Solubilization and thiamine tr ...
Electrophorus electricus
Biochim. Biophys. Acta
1073
69-76
1991
4
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3
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210024
Bettendorff
Application of high-performanc ...
Electrophorus electricus
J. Chromatogr.
566
397-408
1991
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210019
Nishimune
Hydrolysis and synthesis of th ...
Aneurinibacillus aneurinilyticus, Escherichia coli, Escherichia coli W 1485
J. Nutr. Sci. Vitaminol.
33
113-127
1987
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3
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2
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210018
Ogawa
Recent findings on ultracytoch ...
Rattus norvegicus
Ann. N. Y. Acad. Sci.
378
188-214
1982
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4
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210017
Penttinen
The relation of the soluble th ...
Rattus norvegicus
Med. Biol.
59
177-184
1981
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7
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210013
Barchi
Membrane-associated thiamin tr ...
Rattus norvegicus
J. Biol. Chem.
251
193-197
1976
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210014
Barchi
Membrane thiamine triphosphata ...
Rattus norvegicus
J. Neurochem.
26
715-720
1976
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4
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2
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210011
Iwata
Properties of thiamine di- and ...
Rattus norvegicus
J. Neurochem.
24
1209-1213
1975
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210009
Iwata
Role of thiamine metabolism in ...
Rattus norvegicus
Jpn. J. Pharmacol.
24
825-829
1974
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2
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1
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210010
Iwata
Role of thiamine metabolism in ...
Rattus norvegicus
Jpn. J. Pharmacol.
24
817-823
1974
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210015
Iwata
-
Some properties of the enzyme ...
Rattus norvegicus
Thiamine (Proc. Pap. U. S. -Jpn. Semin, 2. Meeting)
2. Meeting
213-221
1974
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210016
Barchi
-
Thiamine triphosphatases in br ...
Rattus norvegicus
Thiamine (Proc. Pap. U. S. -Jpn. Semin, 2. Meeting)
195-212
1974
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2
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210006
Barchi
A membrane-associated thiamine ...
Rattus norvegicus
J. Biol. Chem.
247
7668-7673
1972
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3
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1
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1
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8
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2
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210007
Hashitani
The partial purification of th ...
Rattus norvegicus
J. Biol. Chem.
247
2117-2119
1972
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1
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1
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210008
Barchi
Thiamine triphosphatase in the ...
Rattus norvegicus
Biochim. Biophys. Acta
255
402-405
1972
1
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