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Literature summary for 3.6.1.28 extracted from
- Some properties of the enzyme system degrading phosphorylated thiamines in the brain and the effect of chlorpromazine (1974), Thiamine (Proc. Pap. U. S. -Jpn. Semin, 2. Meeting), 2. Meeting, 213-221.
No PubMed abstract available
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| chlorpromazine | microsomal and soluble enzyme; no inhibition in presence of Ca2+ | Rattus norvegicus |  |
| deoxycholate | 0.02% w/v | Rattus norvegicus | |
| desipramine | microsomal and soluble enzyme | Rattus norvegicus | |
| imipramine | microsomal and soluble enzyme | Rattus norvegicus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| microsome | - |
Rattus norvegicus | - |
- |
| soluble | - |
Rattus norvegicus | - |
- |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Ca2+ | divalent cation requirement is satisfied by Mg2+ or Ca2+ | Rattus norvegicus | |
| Mg2+ | divalent cation requirement is satisfied by Mg2+ or Ca2+ | Rattus norvegicus | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Rattus norvegicus | - |
| liver | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| thiamine triphosphate + H2O | - |
Rattus norvegicus | thiamine diphosphate + phosphate | - |
? | |
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Release 2023.1 (January 2023)
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