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Literature summary for 3.6.1.27 extracted from

  • Jalal, N.; Tian, X.L.; Dong, G.; Upham, J.; Chen, C.; Parcells, M.; Li, Y.H.
    Identification and characterization of SMU.244 encoding a putative undecaprenyl pyrophosphate phosphatase protein required for cell wall biosynthesis and bacitracin resistance in Streptococcus mutans (2015), Microbiology, 161, 1857-1870 .
    View publication on PubMed
Search for more literature for 3.6.1.27

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli BL21(DE3)pLyS cells Streptococcus mutans

Inhibitors

Inhibitors Comment Organism Structure
EDTA complete inhibition at 5 mM Streptococcus mutans

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
 Streptococcus mutans 16020
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ 10 mM used in assay conditions Streptococcus mutans

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
undecaprenyl diphosphate + H2O Streptococcus mutans
-
 undecaprenyl phosphate + phosphate
-
 ?
undecaprenyl diphosphate + H2O Streptococcus mutans WT UA159
-
 undecaprenyl phosphate + phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Streptococcus mutans
-
-
-
Streptococcus mutans WT UA159
-
-
-

Purification (Commentary)

Purification (Comment) Organism
Ni-charged resin column chromatography Streptococcus mutans

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
farnesyl diphosphate + H2O
-
 Streptococcus mutans farnesyl phosphate + phosphate
-
 ?
farnesyl diphosphate + H2O
-
 Streptococcus mutans WT UA159 farnesyl phosphate + phosphate
-
 ?
undecaprenyl diphosphate + H2O
-
 Streptococcus mutans undecaprenyl phosphate + phosphate
-
 ?
undecaprenyl diphosphate + H2O
-
 Streptococcus mutans WT UA159 undecaprenyl phosphate + phosphate
-
 ?

Subunits

Subunits Comment Organism
? x * 31232, calculated from amino acid sequence Streptococcus mutans

Synonyms

Synonyms Comment Organism
SMU.244 locus name Streptococcus mutans
undecaprenyl pyrophosphate phosphatase
-
 Streptococcus mutans
UppP
-
 Streptococcus mutans

pI Value

Organism Comment pI Value Maximum pI Value
Streptococcus mutans calculated from amino acid sequence
-
 10

Expression

Organism Comment Expression
Streptococcus mutans enzyme expression is induced by a sub-MIC of bacitracin up

General Information

General Information Comment Organism
malfunction enzyme deletion results in a mutant with reduced biofilm formation that is highly sensitive to bacitracin, but confers more resistance to lactococcin G Streptococcus mutans
physiological function the enzyme plays important roles in cell wall biosynthesis and bacitracin resistance Streptococcus mutans