BRENDA - Enzyme Database show
show all sequences of 3.6.1.27

Tripropeptin C blocks the lipid cycle of cell wall biosynthesis by complex formation with undecaprenyl pyrophosphate

Hashizume, H.; Sawa, R.; Harada, S.; Igarashi, M.; Adachi, H.; Nishimura, Y.; Nomoto, A.; Antimicrob. Agents Chemother. 55, 3821-3828 (2011)

Data extracted from this reference:

Inhibitors
Inhibitors
Commentary
Organism
Structure
bacitracin
-
Micrococcus luteus
tripropeptin C
tripropeptin C can potentially inhibit C55-PP phosphatase activity, which plays a crucial role in the lipid cycle of peptidoglycan synthesis
Micrococcus luteus
Localization
Localization
Commentary
Organism
GeneOntology No.
Textmining
membrane
-
Micrococcus luteus
16020
-
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Micrococcus luteus
C5CBT8
-
-
IC50 Value
IC50 Value
IC50 Value Maximum
Commentary
Organism
Inhibitor
Structure
0.00003
0.0001
in 100 mM Tris-HCl, 10 mM MgCl2 and 3.9 mM n-dodecyl-beta-maltoside (pH 7.5), 1.25 mM CaCl2, at 30C
Micrococcus luteus
tripropeptin C
IC50 Value (protein specific)
IC50 Value
IC50 Value Maximum
Commentary
Organism
Inhibitor
Structure
0.00003
0.0001
in 100 mM Tris-HCl, 10 mM MgCl2 and 3.9 mM n-dodecyl-beta-maltoside (pH 7.5), 1.25 mM CaCl2, at 30C
Micrococcus luteus
tripropeptin C
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
bacitracin
-
Micrococcus luteus
tripropeptin C
tripropeptin C can potentially inhibit C55-PP phosphatase activity, which plays a crucial role in the lipid cycle of peptidoglycan synthesis
Micrococcus luteus
Localization (protein specific)
Localization
Commentary
Organism
GeneOntology No.
Textmining
membrane
-
Micrococcus luteus
16020
-
Other publictions for EC 3.6.1.27
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [C]
Temperature Range [C]
Temperature Stability [C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [C] (protein specific)
Temperature Range [C] (protein specific)
Temperature Stability [C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
734263
Chang
Proposed carrier lipid-binding ...
Escherichia coli
J. Biol. Chem.
289
18719-18735
2014
-
-
1
-
17
-
2
1
-
2
1
-
-
2
-
-
-
-
-
-
-
-
1
1
-
-
-
1
1
-
-
-
1
-
1
-
-
1
-
-
17
-
1
2
1
1
-
2
1
-
-
-
-
-
-
-
-
-
1
1
-
-
-
1
1
-
-
-
-
-
-
-
-
-
734038
Shaaly
Undecaprenyl pyrophosphate pho ...
Enterococcus faecalis
J. Antimicrob. Chemother.
68
1583-1593
2013
-
-
-
-
-
-
-
-
-
-
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3
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-
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1
1
1
1
-
-
718534
Coker
-
Current understanding of de no ...
Bacillus subtilis, Escherichia coli
Afr. J. Microbiol. Res.
5
2555-2565
2011
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-
-
-
-
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2
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2
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2
2
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718588
Hashizume
Tripropeptin C blocks the lipi ...
Micrococcus luteus
Antimicrob. Agents Chemother.
55
3821-3828
2011
-
-
-
-
-
-
2
-
1
-
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-
-
1
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1
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2
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1
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-
-
-
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-
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713052
Hynninen
An efflux transporter PbrA and ...
Cupriavidus metallidurans, Cupriavidus metallidurans CH34
Mol. Microbiol.
74
384-394
2009
-
-
1
-
-
-
2
-
1
-
-
-
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9
-
-
1
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12
-
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1
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2
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1
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1
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12
-
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-
687718
Touze
Substrate specificity and memb ...
Escherichia coli
J. Biol. Chem.
283
16573-16583
2008
4
-
1
-
-
-
-
6
3
-
3
1
-
2
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1
-
-
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5
-
8
2
1
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6
1
1
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4
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1
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6
3
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3
1
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1
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5
-
8
2
1
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6
1
1
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-
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-
688861
Tatar
An Escherichia coli undecapren ...
Escherichia coli
Microbiology
153
2518-2529
2007
-
-
-
-
1
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2
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1
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2
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1
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2
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1
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2
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1
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1
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2
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669336
El Ghachi
Identification of multiple gen ...
Escherichia coli
J. Biol. Chem.
280
18689-18695
2005
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2
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1
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669366
Bernard
BcrC from Bacillus subtilis ac ...
Bacillus subtilis
J. Biol. Chem.
280
28852-28857
2005
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2
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4
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210607
Goldman
Purification and properties of ...
Micrococcus luteus
J. Biol. Chem.
247
5116-5122
1972
6
-
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1
5
1
1
1
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1
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1
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1
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2
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4
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1
1
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6
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1
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5
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1
1
1
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1
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1
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2
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4
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1
1
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210606
Stone
Mechanism of action of bacitra ...
Enterococcus faecalis
Proc. Natl. Acad. Sci. USA
68
3223-3227
1971
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1
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9
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1
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1
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