Literature summary for 3.6.1.27 extracted from

Tatar, L.D.; Marolda, C.L.; Polischuk, A.N.; van Leeuwen, D.; Valvano, M.A.
An Escherichia coli undecaprenyl-pyrophosphate phosphatase implicated in undecaprenyl phosphate recycling (2007), Microbiology, 153, 2518-2529.

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Protein Variants

Protein Variants	Comment	Organism
additional information	construction of chromosomal gene deletions mutants, double and triple deletion mutants in the genes uppP and ybjG, and uppP, ybjG and yeiU, respectively, are supersensitive to the Und-P de novo biosynthesis inhibitor fosmidomycin, while single or combined deletions including pgpB have no effect on fosmidomycin supersensitivity, overview	Escherichia coli

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
cytoplasm	UppP and UppS exert their enzymic activity on the cytoplasmic side of the plasma membrane	Escherichia coli	5737	-
periplasm	YbjG and, to a lesser extent, YeiU exert their enzymic activity on the periplasmic side of the plasma membrane	Escherichia coli	-	-

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
undecaprenyl diphosphate + H2O	Escherichia coli	the dephosphorylation of Und-PP, from de novo synthesis, produces undecaprenyl phosphate, a universal lipid carrier of glycan biosynthetic intermediates for carbohydrate polymers that are exported to the bacterial cell envelope, YbjG and YeiU are implicated in the recycling of periplasmic Und-PP molecules	undecaprenyl phosphate + phosphate	-	?

Organism

Organism	UniProt	Comment	Textmining
Escherichia coli	-	genes uppP, ybjG, and yeiU	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
additional information	UppP accounts for 75% of the total cellular Und-PP pyrophosphatase activity	Escherichia coli	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
undecaprenyl diphosphate + H2O	-	Escherichia coli	undecaprenyl phosphate + phosphate	-	?
undecaprenyl diphosphate + H2O	the dephosphorylation of Und-PP, from de novo synthesis, produces undecaprenyl phosphate, a universal lipid carrier of glycan biosynthetic intermediates for carbohydrate polymers that are exported to the bacterial cell envelope, YbjG and YeiU are implicated in the recycling of periplasmic Und-PP molecules	Escherichia coli	undecaprenyl phosphate + phosphate	-	?

Synonyms

Synonyms	Comment	Organism
undecaprenyl-pyrophosphate phosphatase	-	Escherichia coli
UppP	formerly BacA	Escherichia coli
YbjG	-	Escherichia coli
YeiU	-	Escherichia coli

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Release 2023.1 (January 2023)