BRENDA - Enzyme Database show
show all sequences of 3.6.1.27

Mechanism of action of bacitracin: complexation with metal ion and C 55 -isoprenyl pyrophosphate

Stone, K.J.; Strominger, J.L.; Proc. Natl. Acad. Sci. USA 68, 3223-3227 (1971)

Data extracted from this reference:

Inhibitors
Inhibitors
Commentary
Organism
Structure
bacitracin
complex formation with substrate + metal ion, reversed by addition of chelating agents
Enterococcus faecalis
Localization
Localization
Commentary
Organism
GeneOntology No.
Textmining
membrane
-
Enterococcus faecalis
16020
-
Metals/Ions
Metals/Ions
Commentary
Organism
Structure
Ca2+
enhances inhibitory effect of bacitacin
Enterococcus faecalis
Cd2+
enhances inhibitory effect of bacitacin, slight inhibitory effect without bacitracin
Enterococcus faecalis
Co2+
enhances inhibitory effect of bacitacin, slight inhibitory effect without bacitracin
Enterococcus faecalis
Cu2+
enhances inhibitory effect of bacitacin
Enterococcus faecalis
Fe2+
enhances inhibitory effect of bacitacin, slight inhibitory effect without bacitracin
Enterococcus faecalis
Mg2+
enhances inhibitory effect of bacitacin
Enterococcus faecalis
Mn2+
enhances inhibitory effect of bacitacin, slight inhibitory effect without bacitracin
Enterococcus faecalis
additional information
no requirement for added metal ions
Enterococcus faecalis
Zn2+
enhances inhibitory effect of bacitacin
Enterococcus faecalis
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
undecaprenyl diphosphate + H2O
Enterococcus faecalis
involved in cyclic peptidoglycan pathway
undecaprenyl phosphate + phosphate
-
Enterococcus faecalis
?
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Enterococcus faecalis
-
-
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
undecaprenyl diphosphate + H2O
-
210606
Enterococcus faecalis
undecaprenyl phosphate + phosphate
-
210606
Enterococcus faecalis
?
undecaprenyl diphosphate + H2O
involved in cyclic peptidoglycan pathway
210606
Enterococcus faecalis
undecaprenyl phosphate + phosphate
-
210606
Enterococcus faecalis
?
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
bacitracin
complex formation with substrate + metal ion, reversed by addition of chelating agents
Enterococcus faecalis
Localization (protein specific)
Localization
Commentary
Organism
GeneOntology No.
Textmining
membrane
-
Enterococcus faecalis
16020
-
Metals/Ions (protein specific)
Metals/Ions
Commentary
Organism
Structure
Ca2+
enhances inhibitory effect of bacitacin
Enterococcus faecalis
Cd2+
enhances inhibitory effect of bacitacin, slight inhibitory effect without bacitracin
Enterococcus faecalis
Co2+
enhances inhibitory effect of bacitacin, slight inhibitory effect without bacitracin
Enterococcus faecalis
Cu2+
enhances inhibitory effect of bacitacin
Enterococcus faecalis
Fe2+
enhances inhibitory effect of bacitacin, slight inhibitory effect without bacitracin
Enterococcus faecalis
Mg2+
enhances inhibitory effect of bacitacin
Enterococcus faecalis
Mn2+
enhances inhibitory effect of bacitacin, slight inhibitory effect without bacitracin
Enterococcus faecalis
additional information
no requirement for added metal ions
Enterococcus faecalis
Zn2+
enhances inhibitory effect of bacitacin
Enterococcus faecalis
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
undecaprenyl diphosphate + H2O
Enterococcus faecalis
involved in cyclic peptidoglycan pathway
undecaprenyl phosphate + phosphate
-
Enterococcus faecalis
?
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
undecaprenyl diphosphate + H2O
-
210606
Enterococcus faecalis
undecaprenyl phosphate + phosphate
-
210606
Enterococcus faecalis
?
undecaprenyl diphosphate + H2O
involved in cyclic peptidoglycan pathway
210606
Enterococcus faecalis
undecaprenyl phosphate + phosphate
-
210606
Enterococcus faecalis
?
Other publictions for EC 3.6.1.27
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
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5
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8
2
1
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6
1
1
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4
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1
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6
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3
1
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5
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8
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6
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An Escherichia coli undecapren ...
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669336
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280
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2
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1
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1
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669366
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BcrC from Bacillus subtilis ac ...
Bacillus subtilis
J. Biol. Chem.
280
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2005
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2
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4
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3
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Goldman
Purification and properties of ...
Micrococcus luteus
J. Biol. Chem.
247
5116-5122
1972
6
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1
5
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1
1
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1
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4
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6
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5
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1
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1
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1
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1
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2
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4
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1
1
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210606
Stone
Mechanism of action of bacitra ...
Enterococcus faecalis
Proc. Natl. Acad. Sci. USA
68
3223-3227
1971
-
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1
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9
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1
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1
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2
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