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Literature summary for 3.6.1.23 extracted from

  • Hampton, S.E.; Schipani, A.; Bosch-Navarrete, C.; Recio, E.; Kaiser, M.; Kahnberg, P.; Gonzalez-Pacanowska, D.; Johansson, N.G.; Gilbert, I.H.
    Investigation of acyclic uridine amide and 5-amido nucleoside analogues as potential inhibitors of the Plasmodium falciparum dUTPase (2013), Bioorg. Med. Chem., 21, 5876-5885.
    View publication on PubMedView publication on EuropePMC
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Inhibitors

Inhibitors Comment Organism Structure
1-[3-(benzhydrylaminocarbonyl)propyl]uracil 1429fold selectivity over human enzyme Plasmodium falciparum
1-[3-(tritylaminocarbonyl)propyl]uracil 4545fold selectivity over human enzyme Plasmodium falciparum

Organism

Organism UniProt Comment Textmining
Plasmodium falciparum
-
-
-

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0002
-
 1-[3-(tritylaminocarbonyl)propyl]uracil pH 8.0, temperature not specified in the publication Plasmodium falciparum
0.0007
-
 1-[3-(benzhydrylaminocarbonyl)propyl]uracil pH 8.0, temperature not specified in the publication Plasmodium falciparum